Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease.

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Title: Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease.
Authors: Kopal J; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada., Vo A; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Tao Q; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Simuni T; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chahine LM; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Bzdok D; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada. danilo.bzdok@mcgill.ca.; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. danilo.bzdok@mcgill.ca.; Mila - Quebec Artificial Intelligence Institute, Montréal, QC, Canada. danilo.bzdok@mcgill.ca., Dagher A; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.; Department of Neurology and neurosurgery, McGill University, Montréal, QC, Canada.
Source: Communications medicine [Commun Med (Lond)] 2026 Jan 03; Vol. 6 (1), pp. 71. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond) Subsets: PubMed not MEDLINE
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  Data: Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Kopal+J%22">Kopal J</searchLink>; Centre for Precision Psychiatry, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Vo+A%22">Vo A</searchLink>; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Tao+Q%22">Tao Q</searchLink>; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Simuni+T%22">Simuni T</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chahine+LM%22">Chahine LM</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bzdok+D%22">Bzdok D</searchLink>; Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada. danilo.bzdok@mcgill.ca.; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. danilo.bzdok@mcgill.ca.; Mila - Quebec Artificial Intelligence Institute, Montréal, QC, Canada. danilo.bzdok@mcgill.ca.<br /><searchLink fieldCode="AU" term="%22Dagher+A%22">Dagher A</searchLink>; The Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.; Department of Neurology and neurosurgery, McGill University, Montréal, QC, Canada.
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  Data: <searchLink fieldCode="JN" term="%229918250414506676%22">Communications medicine</searchLink> [Commun Med (Lond)] 2026 Jan 03; Vol. 6 (1), pp. 71. <i>Date of Electronic Publication: </i>2026 Jan 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918250414506676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-664X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222730664X%22">2730664X </searchLink><i>NLM ISO Abbreviation: </i>Commun Med (Lond) <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s43856-025-01330-7
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      – TitleFull: Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson's disease.
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              Text: 2026 Jan 03
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