TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.
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| Title: | TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway. |
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| Authors: | Perez-Borrajero C; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. cecilia.perez@embl.de., Stein F; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Schweimer K; Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth, Germany., Rettel M; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Schwarz JJ; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Haberkant P; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Lapouge K; Protein Expression and Purification Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Gayk J; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hoffmann T; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Bhogaraju S; Structural Biology Unit, European Molecular Biology Laboratory, Grenoble, France., Noh KM; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Savitski M; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Mahamid J; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hennig J; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. janosch.hennig@uni-bayreuth.de.; Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth, Germany. janosch.hennig@uni-bayreuth.de. |
| Source: | EMBO reports [EMBO Rep] 2026 Feb; Vol. 27 (3), pp. 729-747. Date of Electronic Publication: 2026 Jan 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-025-00667-3 |
