View in EDS HTML Full Text PDF Full Text

TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.

Saved in:
Bibliographic Details
Title: TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.
Authors: Perez-Borrajero C; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. cecilia.perez@embl.de., Stein F; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Schweimer K; Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth, Germany., Rettel M; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Schwarz JJ; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Haberkant P; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Lapouge K; Protein Expression and Purification Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Gayk J; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hoffmann T; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Bhogaraju S; Structural Biology Unit, European Molecular Biology Laboratory, Grenoble, France., Noh KM; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Savitski M; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Mahamid J; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hennig J; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. janosch.hennig@uni-bayreuth.de.; Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth, Germany. janosch.hennig@uni-bayreuth.de.
Source: EMBO reports [EMBO Rep] 2026 Feb; Vol. 27 (3), pp. 729-747. Date of Electronic Publication: 2026 Jan 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41484378
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Perez-Borrajero+C%22">Perez-Borrajero C</searchLink>; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. cecilia.perez@embl.de.<br /><searchLink fieldCode="AU" term="%22Stein+F%22">Stein F</searchLink>; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schweimer+K%22">Schweimer K</searchLink>; Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth, Germany.<br /><searchLink fieldCode="AU" term="%22Rettel+M%22">Rettel M</searchLink>; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwarz+JJ%22">Schwarz JJ</searchLink>; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Haberkant+P%22">Haberkant P</searchLink>; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lapouge+K%22">Lapouge K</searchLink>; Protein Expression and Purification Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gayk+J%22">Gayk J</searchLink>; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+T%22">Hoffmann T</searchLink>; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bhogaraju+S%22">Bhogaraju S</searchLink>; Structural Biology Unit, European Molecular Biology Laboratory, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Noh+KM%22">Noh KM</searchLink>; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Savitski+M%22">Savitski M</searchLink>; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Proteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mahamid+J%22">Mahamid J</searchLink>; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hennig+J%22">Hennig J</searchLink>; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. janosch.hennig@uni-bayreuth.de.; Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth, Germany. janosch.hennig@uni-bayreuth.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22100963049%22">EMBO reports</searchLink> [EMBO Rep] 2026 Feb; Vol. 27 (3), pp. 729-747. <i>Date of Electronic Publication: </i>2026 Jan 03.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100963049 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-3178 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221469221X%22">1469221X </searchLink><i>NLM ISO Abbreviation: </i>EMBO Rep <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41484378
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44319-025-00667-3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 729
    Titles:
      – TitleFull: TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Perez-Borrajero C
      – PersonEntity:
          Name:
            NameFull: Stein F
      – PersonEntity:
          Name:
            NameFull: Schweimer K
      – PersonEntity:
          Name:
            NameFull: Rettel M
      – PersonEntity:
          Name:
            NameFull: Schwarz JJ
      – PersonEntity:
          Name:
            NameFull: Haberkant P
      – PersonEntity:
          Name:
            NameFull: Lapouge K
      – PersonEntity:
          Name:
            NameFull: Gayk J
      – PersonEntity:
          Name:
            NameFull: Hoffmann T
      – PersonEntity:
          Name:
            NameFull: Bhogaraju S
      – PersonEntity:
          Name:
            NameFull: Noh KM
      – PersonEntity:
          Name:
            NameFull: Savitski M
      – PersonEntity:
          Name:
            NameFull: Mahamid J
      – PersonEntity:
          Name:
            NameFull: Hennig J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1469-3178
          Numbering:
            – Type: volume
              Value: 27
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: EMBO reports
              Type: main
ResultId 1