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Repurposing of ivacaftor shows potential to treat ROR1 expressing high-grade serous ovarian cancer.

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Title: Repurposing of ivacaftor shows potential to treat ROR1 expressing high-grade serous ovarian cancer.
Authors: Liu D; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Wong-Brown M; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia., Sarker FA; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Matthews B; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia., Morrison J; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia., Dickson KA; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Alghalayini A; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Stojanova J; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital Sydney, Sydney, NSW, Australia., Wan KM; Gynaecological Oncology Department, Royal Hospital for Women, Sydney, NSW, Australia., Duggan J; Gynaecological Oncology Department, Royal Hospital for Women, Sydney, NSW, Australia., Loo C; Department of Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Sydney, NSW, Australia., Stannard G; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia., Powell E; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Hodder B; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Barlow E; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Marsh DJ; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Ford CE; Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia., Bowden NA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Source: Therapeutic advances in medical oncology [Ther Adv Med Oncol] 2026 Jan 02; Vol. 18, pp. 17588359251409010. Date of Electronic Publication: 2026 Jan 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Sage Country of Publication: England NLM ID: 101510808 Publication Model: eCollection Cited Medium: Print ISSN: 1758-8340 (Print) Linking ISSN: 17588340 NLM ISO Abbreviation: Ther Adv Med Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Repurposing of ivacaftor shows potential to treat ROR1 expressing high-grade serous ovarian cancer.
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  Data: <searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wong-Brown+M%22">Wong-Brown M</searchLink>; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sarker+FA%22">Sarker FA</searchLink>; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Matthews+B%22">Matthews B</searchLink>; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Morrison+J%22">Morrison J</searchLink>; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dickson+KA%22">Dickson KA</searchLink>; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Alghalayini+A%22">Alghalayini A</searchLink>; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Stojanova+J%22">Stojanova J</searchLink>; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wan+KM%22">Wan KM</searchLink>; Gynaecological Oncology Department, Royal Hospital for Women, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Duggan+J%22">Duggan J</searchLink>; Gynaecological Oncology Department, Royal Hospital for Women, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Loo+C%22">Loo C</searchLink>; Department of Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Stannard+G%22">Stannard G</searchLink>; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Powell+E%22">Powell E</searchLink>; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hodder+B%22">Hodder B</searchLink>; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Barlow+E%22">Barlow E</searchLink>; Gynaecological Cancer Research Group, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Marsh+DJ%22">Marsh DJ</searchLink>; Translational Oncology Group, School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ford+CE%22">Ford CE</searchLink>; Gynaecological Cancer Research Group, Lowy Cancer Research Centre and School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Bowden+NA%22">Bowden NA</searchLink>; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.; Equity in Health and Wellbeing Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101510808%22">Therapeutic advances in medical oncology</searchLink> [Ther Adv Med Oncol] 2026 Jan 02; Vol. 18, pp. 17588359251409010. <i>Date of Electronic Publication: </i>2026 Jan 02 (<i>Print Publication: </i>2026).
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