Sigma receptors and mitochondria-associated ER membranes are converging therapeutic targets for Alzheimer's disease.

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Title: Sigma receptors and mitochondria-associated ER membranes are converging therapeutic targets for Alzheimer's disease.
Authors: Lotlikar MS; Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Henry and Allison McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States., Zellmer JC; Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Henry and Allison McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States., Bhattacharyya R; Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Henry and Allison McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Source: Frontiers in neuroscience [Front Neurosci] 2025 Dec 19; Vol. 19, pp. 1733659. Date of Electronic Publication: 2025 Dec 19 (Print Publication: 2025).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lotlikar+MS%22">Lotlikar MS</searchLink>; Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Henry and Allison McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.<br /><searchLink fieldCode="AU" term="%22Zellmer+JC%22">Zellmer JC</searchLink>; Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Henry and Allison McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.<br /><searchLink fieldCode="AU" term="%22Bhattacharyya+R%22">Bhattacharyya R</searchLink>; Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease, Henry and Allison McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
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  Data: <searchLink fieldCode="JN" term="%22101478481%22">Frontiers in neuroscience</searchLink> [Front Neurosci] 2025 Dec 19; Vol. 19, pp. 1733659. <i>Date of Electronic Publication: </i>2025 Dec 19 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101478481 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1662-4548 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221662453X%22">1662453X </searchLink><i>NLM ISO Abbreviation: </i>Front Neurosci <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.3389/fnins.2025.1733659
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              Text: 2025 Dec 19
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