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Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents.

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Title: Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents.
Authors: Arab F; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Saleh SA; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Ibrahim DM; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt., Barakat AN; Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt., Yousef AA; Department of Pediatrics, Faculty of Medicine, Capital University (formerly Helwan University), Administrative Capital, Egypt., Abdulhay M; Department of Pediatrics, Faculty of Medicine, Capital University (formerly Helwan University), Administrative Capital, Egypt., Haridi MK; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt., Al-Fahham MM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Selim DM; Al-Adan New Women & Children Hospital, Kuwait City, Kuwait., Ismail AH; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Younis MMS; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Soliman AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Shehata H; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Ashraf B; Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Nabil RM; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdelnaser MM; Department of Medical Microbiology and Immunology, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., AbdelKareem MZ; Department of Medical Microbiology and Immunology, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Afify MR; Department of basic medical science, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Bakhsh WK; Department of basic medical science, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Alkashgari HR; Department of basic medical science, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Almoraie LM; SDFM. Family Medicine Registrar, Department of Family Medicine, University Medical Center, University of Jeddah, Jeddah, Saudi Arabia., Shalabi MS; Pediatric Department , Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Khazindar AR; Department of Radiology, University of Jeddah, College of Medicine, Jeddah, Saudi Arabia., Bawazir Y; Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Mustafa M; Department of Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Daghistani Y; Department of Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Alomari RA; Department of Pathology and Laboratory Medicine, Ministry of National Guard health affairs, Jeddah, Saudi Arabia., Balkhair AA; Department of Pathology and Laboratory Medicine, Ministry of National Guard health affairs, Jeddah, Saudi Arabia., Alhusaini WI; Pediatric Saudi Board KAAUH, Pediatric Infectious Disease Consultant, Assistant Professor, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Abdel Raouf BM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Elmikaty HA; Researcher of Pediatrics-National Research Centre, Cairo, Egypt., Taha S; Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Gaaly SAA; Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Ayad ASAM; Department of Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Abdalla H; Department of Chest diseases, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Sayed ME; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Shoaeir MZ; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Abass AS; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Abdel-Aziz TM; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt., Emam AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Source: Lupus [Lupus] 2026 Mar; Vol. 35 (3), pp. 280-288. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents.
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  Data: <searchLink fieldCode="AU" term="%22Arab+F%22">Arab F</searchLink>; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Saleh+SA%22">Saleh SA</searchLink>; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ibrahim+DM%22">Ibrahim DM</searchLink>; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Barakat+AN%22">Barakat AN</searchLink>; Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.<br /><searchLink fieldCode="AU" term="%22Yousef+AA%22">Yousef AA</searchLink>; Department of Pediatrics, Faculty of Medicine, Capital University (formerly Helwan University), Administrative Capital, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdulhay+M%22">Abdulhay M</searchLink>; Department of Pediatrics, Faculty of Medicine, Capital University (formerly Helwan University), Administrative Capital, Egypt.<br /><searchLink fieldCode="AU" term="%22Haridi+MK%22">Haridi MK</searchLink>; Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Fahham+MM%22">Al-Fahham MM</searchLink>; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Selim+DM%22">Selim DM</searchLink>; Al-Adan New Women & Children Hospital, Kuwait City, Kuwait.<br /><searchLink fieldCode="AU" term="%22Ismail+AH%22">Ismail AH</searchLink>; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Younis+MMS%22">Younis MMS</searchLink>; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Soliman+AA%22">Soliman AA</searchLink>; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Shehata+H%22">Shehata H</searchLink>; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Ashraf+B%22">Ashraf B</searchLink>; Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.<br /><searchLink fieldCode="AU" term="%22Nabil+RM%22">Nabil RM</searchLink>; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelnaser+MM%22">Abdelnaser MM</searchLink>; Department of Medical Microbiology and Immunology, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22AbdelKareem+MZ%22">AbdelKareem MZ</searchLink>; Department of Medical Microbiology and Immunology, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Afify+MR%22">Afify MR</searchLink>; Department of basic medical science, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Bakhsh+WK%22">Bakhsh WK</searchLink>; Department of basic medical science, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alkashgari+HR%22">Alkashgari HR</searchLink>; Department of basic medical science, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Almoraie+LM%22">Almoraie LM</searchLink>; SDFM. Family Medicine Registrar, Department of Family Medicine, University Medical Center, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Shalabi+MS%22">Shalabi MS</searchLink>; Pediatric Department , Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Khazindar+AR%22">Khazindar AR</searchLink>; Department of Radiology, University of Jeddah, College of Medicine, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Bawazir+Y%22">Bawazir Y</searchLink>; Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mustafa+M%22">Mustafa M</searchLink>; Department of Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Daghistani+Y%22">Daghistani Y</searchLink>; Department of Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alomari+RA%22">Alomari RA</searchLink>; Department of Pathology and Laboratory Medicine, Ministry of National Guard health affairs, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Balkhair+AA%22">Balkhair AA</searchLink>; Department of Pathology and Laboratory Medicine, Ministry of National Guard health affairs, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alhusaini+WI%22">Alhusaini WI</searchLink>; Pediatric Saudi Board KAAUH, Pediatric Infectious Disease Consultant, Assistant Professor, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abdel+Raouf+BM%22">Abdel Raouf BM</searchLink>; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elmikaty+HA%22">Elmikaty HA</searchLink>; Researcher of Pediatrics-National Research Centre, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Taha+S%22">Taha S</searchLink>; Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Gaaly+SAA%22">El-Gaaly SAA</searchLink>; Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ayad+ASAM%22">Ayad ASAM</searchLink>; Department of Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdalla+H%22">Abdalla H</searchLink>; Department of Chest diseases, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Sayed+ME%22">Sayed ME</searchLink>; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Shoaeir+MZ%22">Shoaeir MZ</searchLink>; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Abass+AS%22">Abass AS</searchLink>; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdel-Aziz+TM%22">Abdel-Aziz TM</searchLink>; Department of Rheumatology and rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Emam+AA%22">Emam AA</searchLink>; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
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