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CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment.

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Title: CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment.
Authors: Amelan A; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Collins SC; INSERM Unit 1231, Université de Bourgogne-Europe, Dijon, France.; Institut NeuroMyoGène, Unité Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France., Damseh NS; Department of Pediatrics & Genetics, Makassed Hospital & Al-Quds Medical School, East Jerusalem, Palestine., Hamada N; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan., Salim A; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Dvir E; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Monderer-Rothkoff G; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Harel T; Department of Genetics, Hadassah Medical Center, Jerusalem, Israel.; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Nagata KI; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.; Department of Neurochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan., Yalcin B; INSERM Unit 1231, Université de Bourgogne-Europe, Dijon, France. binnaz.yalcin@inserm.fr.; Institut NeuroMyoGène, Unité Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France. binnaz.yalcin@inserm.fr., Shifman S; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel. sagiv.shifman@mail.huji.ac.il.
Source: Nature neuroscience [Nat Neurosci] 2026 Mar; Vol. 29 (3), pp. 592-603. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: CRISPR knockout screens reveal genes and pathways essential for neuronal differentiation and implicate PEDS1 in neurodevelopment.
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  Data: <searchLink fieldCode="AU" term="%22Amelan+A%22">Amelan A</searchLink>; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Collins+SC%22">Collins SC</searchLink>; INSERM Unit 1231, Université de Bourgogne-Europe, Dijon, France.; Institut NeuroMyoGène, Unité Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Damseh+NS%22">Damseh NS</searchLink>; Department of Pediatrics & Genetics, Makassed Hospital & Al-Quds Medical School, East Jerusalem, Palestine.<br /><searchLink fieldCode="AU" term="%22Hamada+N%22">Hamada N</searchLink>; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.<br /><searchLink fieldCode="AU" term="%22Salim+A%22">Salim A</searchLink>; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Dvir+E%22">Dvir E</searchLink>; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Monderer-Rothkoff+G%22">Monderer-Rothkoff G</searchLink>; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Harel+T%22">Harel T</searchLink>; Department of Genetics, Hadassah Medical Center, Jerusalem, Israel.; Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Nagata+KI%22">Nagata KI</searchLink>; Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.; Department of Neurochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Yalcin+B%22">Yalcin B</searchLink>; INSERM Unit 1231, Université de Bourgogne-Europe, Dijon, France. binnaz.yalcin@inserm.fr.; Institut NeuroMyoGène, Unité Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France. binnaz.yalcin@inserm.fr.<br /><searchLink fieldCode="AU" term="%22Shifman+S%22">Shifman S</searchLink>; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel. sagiv.shifman@mail.huji.ac.il.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2026 Mar; Vol. 29 (3), pp. 592-603. <i>Date of Electronic Publication: </i>2026 Jan 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9809671 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210976256%22">10976256 </searchLink><i>NLM ISO Abbreviation: </i>Nat Neurosci <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar
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