Serum H-Ferritin-To-Ferritin Ratio as a Biomarker of Hemophagocytic Lymphohistiocytosis in Critically Ill Patients With Hyperferritinemia.

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Title: Serum H-Ferritin-To-Ferritin Ratio as a Biomarker of Hemophagocytic Lymphohistiocytosis in Critically Ill Patients With Hyperferritinemia.
Authors: Debaugnies F; Laboratory of Translational Research, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.; Medical Biology Department, Laboratoire National de Santé, Dudelange, Luxembourg.; Laboratory of Clinical Chemistry, Centre Hospitalier de Luxembourg, Luxembourg., Goetzinger F; Medical Biology Department, Laboratoire National de Santé, Dudelange, Luxembourg., Wolff F; Clinical Chemistry Department, LHUB-ULB, Université Libre de Bruxelles, Brussels, Belgium., Impens F; VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB, Ghent, Belgium., Dufour S; VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB, Ghent, Belgium., Van Haver D; VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB, Ghent, Belgium., Gottignies P; Department of Intensive Care, Hôpitaux IRIS-Sud, Brussels, Belgium., La Schiazza R; Laboratory of Clinical Chemistry, Centre Hospitalier de Luxembourg, Luxembourg., Mahadeb B; Laboratory of Microbiology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Meuleman N; Hematology Department, Jules Bordet Institute, Brussels, Belgium., Nagant C; Laboratory of Immunology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Rozen L; Laboratory of Hematology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Borde P; Medical Biology Department, Laboratoire National de Santé, Dudelange, Luxembourg., Corazza F; Laboratory of Translational Research, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Immunology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Source: American journal of hematology [Am J Hematol] 2026 Mar; Vol. 101 (3), pp. 648-653. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Letter
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Serum H-Ferritin-To-Ferritin Ratio as a Biomarker of Hemophagocytic Lymphohistiocytosis in Critically Ill Patients With Hyperferritinemia.
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  Data: <searchLink fieldCode="AU" term="%22Debaugnies+F%22">Debaugnies F</searchLink>; Laboratory of Translational Research, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.; Medical Biology Department, Laboratoire National de Santé, Dudelange, Luxembourg.; Laboratory of Clinical Chemistry, Centre Hospitalier de Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Goetzinger+F%22">Goetzinger F</searchLink>; Medical Biology Department, Laboratoire National de Santé, Dudelange, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Wolff+F%22">Wolff F</searchLink>; Clinical Chemistry Department, LHUB-ULB, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Impens+F%22">Impens F</searchLink>; VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Dufour+S%22">Dufour S</searchLink>; VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Haver+D%22">Van Haver D</searchLink>; VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; VIB Proteomics Core, VIB, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Gottignies+P%22">Gottignies P</searchLink>; Department of Intensive Care, Hôpitaux IRIS-Sud, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22La+Schiazza+R%22">La Schiazza R</searchLink>; Laboratory of Clinical Chemistry, Centre Hospitalier de Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Mahadeb+B%22">Mahadeb B</searchLink>; Laboratory of Microbiology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Meuleman+N%22">Meuleman N</searchLink>; Hematology Department, Jules Bordet Institute, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Nagant+C%22">Nagant C</searchLink>; Laboratory of Immunology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Rozen+L%22">Rozen L</searchLink>; Laboratory of Hematology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Borde+P%22">Borde P</searchLink>; Medical Biology Department, Laboratoire National de Santé, Dudelange, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Corazza+F%22">Corazza F</searchLink>; Laboratory of Translational Research, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Immunology, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
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