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Severe Myocarditis Increase in Children Associated With Parvovirus B19 Infection: MYKKE Registry and German Surveillance Data.

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Title: Severe Myocarditis Increase in Children Associated With Parvovirus B19 Infection: MYKKE Registry and German Surveillance Data.
Authors: Seidel F; Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease-Pediatric Cardiology, Berlin, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany. Electronic address: franziska.seidel@dhzc-charite.de., Nygren TM; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany; Postgraduate Training for Applied Epidemiology (PAE), Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany; ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden., Opgen-Rhein B; Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease-Pediatric Cardiology, Berlin, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., Hecht T; Centre for Congenital Heart Disease/Department of Pediatric Cardiology, Heart and Diabetes Centre NRW, University Hospital of the Ruhr University Bochum, Bad Oeynhausen, Germany., Boehne M; Hannover Medical School, Department of Pediatric Cardiology and Intensive Care Medicine, Hannover, Germany., Weickmann J; Heart Centre, University of Leipzig, Clinic for Pediatric Cardiology, Leipzig, Germany., Anderheiden F; University Hospital Erlangen, Department of Pediatric Cardiology, Erlangen, Germany., Reineker K; Department of Congenital Heart Defects and Pediatric Cardiology, University Heart Centre Freiburg-Bad Krozingen, Freiburg, Germany., Böcker D; Department of Pediatric Cardiology, University Heart and Vascular Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Rentzsch A; Department of Pediatric Cardiology, Saarland University Medical Centre, Homburg, Germany., Wiegand G; Department for Pediatric Cardiology, University Hospital Tübingen, Tübingen, Germany., Fischer M; Division of Pediatric Cardiology and Intensive Care Medicine, University Hospital, LMU Munich, Munich, Germany., Kiski D; Department of Pediatric Cardiology, University Hospital Muenster, Muenster, Germany., Frede W; Department Pediatric and Congenital Cardiology, University Medical Centre, Heidelberg, Germany., Ruf B; Department of Pediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, Technische Universität München, Munich, Germany., Tarusinov G; Department of Pediatric Cardiology, Herzzentrum Duisburg, Duisburg, Germany., Papakostas K; Klinikum Bremen Mitte, Eltern-Kind-Zentrum Prof. Hess, Bremen, Germany., Logeswaran T; Department for Pediatric Cardiology, University Hospital Giessen, Giessen, Germany., Schiebel A; Division of Pediatric Cardiology and Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, University Medical Centre Göttingen, Göttingen, Germany., Voges I; University Hospital Schleswig Holstein, Department for Congenital Heart Disease and Pediatric Cardiology, Kiel, Germany; German Centre for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Kaestner M; Division of Pediatric Cardiology, University Hospital, Ulm, Germany., Kramp J; Department of Pediatric Cardiology, University Hospital Cologne, Cologne, Germany., Kerst G; Clinic for Pediatric Cardiology and Congenital Heart Disease, Klinikum Stuttgart, Stuttgart, Germany., Khedim M; Pediatric Cardiology, University Hospital RWTH Aachen, Aachen, Germany., Gatzweiler E; Department of Pediatric Cardiology, University Hospital Bonn, Bonn, Germany., Wannenmacher B; Department of Pediatrics, University Hospital Halle, Halle, Germany., Knirsch W; Pediatric Heart Centre, Pediatric Cardiology, University Children's Hospital Zurich, Zurich, Switzerland., Meyer-Dobkowitz L; Pediatric Cardiology, Klinikum Westbrandenburg, Potsdam, Germany., Donner B; Pediatric Cardiology, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland., Klingner J; Landesuntersuchungsanstalt für das Gesundheits und Veterinärwesen Sachsen, Chemnitz, Germany., Rau C; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany., Haller S; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany., Brinkmann A; Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses, Robert Koch Institute, Berlin, Germany., Nitsche A; Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses, Robert Koch Institute, Berlin, Germany., Noldt M; Public Health Service Hamburg-Wandsbek, Infection Control, Hamburg-Wandsbek, Germany., Schmoock G; Public Health Service Hamburg-Nord, Infection Control, Hamburg-Nord, Germany., Herzmann C; Public Health Authority Stormarn, Infection Control, Bad Oldesloe, Germany., Degenhardt U; Public Health Service Hamburg-Mitte, Hamburg, Germany., Bühler S; Division of Hygiene and Infectious Diseases, Institute for Hygiene and Environment, Hamburg, Germany., Enders M; National Consultant Laboratory for Parvoviruses, Laboratory Prof G. Enders MVZ, Stuttgart, Germany., Hermes J; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany., Rolfs N; Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease-Pediatric Cardiology, Berlin, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany., Manuylova T; Cardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Germany., Schwarzkopf E; Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease-Pediatric Cardiology, Berlin, Germany., Beudt J; National Register for Congenital Heart Defects, Berlin, Germany., Siffczyk C; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany., Schubert S; Centre for Congenital Heart Disease/Department of Pediatric Cardiology, Heart and Diabetes Centre NRW, University Hospital of the Ruhr University Bochum, Bad Oeynhausen, Germany., Sandfort M; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany., Klingel K; Cardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Germany.
Source: JACC. Heart failure [JACC Heart Fail] 2026 May; Vol. 14 (5), pp. 102854. Date of Electronic Publication: 2026 Jan 05.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101598241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1787 (Electronic) Linking ISSN: 22131779 NLM ISO Abbreviation: JACC Heart Fail Subsets: MEDLINE
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  Data: Severe Myocarditis Increase in Children Associated With Parvovirus B19 Infection: MYKKE Registry and German Surveillance Data.
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  Data: <searchLink fieldCode="AU" term="%22Seidel+F%22">Seidel F</searchLink>; Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease-Pediatric Cardiology, Berlin, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany. Electronic address: franziska.seidel@dhzc-charite.de.<br /><searchLink fieldCode="AU" term="%22Nygren+TM%22">Nygren TM</searchLink>; Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany; Postgraduate Training for Applied Epidemiology (PAE), Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany; ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Opgen-Rhein+B%22">Opgen-Rhein B</searchLink>; Deutsches Herzzentrum der Charité, Department of Congenital Heart Disease-Pediatric Cardiology, Berlin, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hecht+T%22">Hecht T</searchLink>; Centre for Congenital Heart Disease/Department of Pediatric Cardiology, Heart and Diabetes Centre NRW, University Hospital of the Ruhr University Bochum, Bad Oeynhausen, Germany.<br /><searchLink fieldCode="AU" term="%22Boehne+M%22">Boehne M</searchLink>; Hannover Medical School, Department of Pediatric Cardiology and Intensive Care Medicine, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Weickmann+J%22">Weickmann J</searchLink>; Heart Centre, University of Leipzig, Clinic for Pediatric Cardiology, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Anderheiden+F%22">Anderheiden F</searchLink>; University Hospital Erlangen, Department of Pediatric Cardiology, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Reineker+K%22">Reineker K</searchLink>; Department of Congenital Heart Defects and Pediatric Cardiology, University Heart Centre Freiburg-Bad Krozingen, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Böcker+D%22">Böcker D</searchLink>; Department of Pediatric Cardiology, University Heart and Vascular Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rentzsch+A%22">Rentzsch A</searchLink>; Department of Pediatric Cardiology, Saarland University Medical Centre, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wiegand+G%22">Wiegand G</searchLink>; Department for Pediatric Cardiology, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+M%22">Fischer M</searchLink>; Division of Pediatric Cardiology and Intensive Care Medicine, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kiski+D%22">Kiski D</searchLink>; Department of Pediatric Cardiology, University Hospital Muenster, Muenster, Germany.<br /><searchLink fieldCode="AU" term="%22Frede+W%22">Frede W</searchLink>; Department Pediatric and Congenital Cardiology, University Medical Centre, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ruf+B%22">Ruf B</searchLink>; Department of Pediatric Cardiology and Congenital Heart Defects, German Heart Centre Munich, Technische Universität München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tarusinov+G%22">Tarusinov G</searchLink>; Department of Pediatric Cardiology, Herzzentrum Duisburg, Duisburg, Germany.<br /><searchLink fieldCode="AU" term="%22Papakostas+K%22">Papakostas K</searchLink>; Klinikum Bremen Mitte, Eltern-Kind-Zentrum Prof. Hess, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Logeswaran+T%22">Logeswaran T</searchLink>; Department for Pediatric Cardiology, University Hospital Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Schiebel+A%22">Schiebel A</searchLink>; Division of Pediatric Cardiology and Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, University Medical Centre Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Voges+I%22">Voges I</searchLink>; University Hospital Schleswig Holstein, Department for Congenital Heart Disease and Pediatric Cardiology, Kiel, Germany; German Centre for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Kaestner+M%22">Kaestner M</searchLink>; Division of Pediatric Cardiology, University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kramp+J%22">Kramp J</searchLink>; Department of Pediatric Cardiology, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kerst+G%22">Kerst G</searchLink>; Clinic for Pediatric Cardiology and Congenital Heart Disease, Klinikum Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Khedim+M%22">Khedim M</searchLink>; Pediatric Cardiology, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Gatzweiler+E%22">Gatzweiler E</searchLink>; Department of Pediatric Cardiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wannenmacher+B%22">Wannenmacher B</searchLink>; Department of Pediatrics, University Hospital Halle, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Knirsch+W%22">Knirsch W</searchLink>; Pediatric Heart Centre, Pediatric Cardiology, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meyer-Dobkowitz+L%22">Meyer-Dobkowitz L</searchLink>; 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