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Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial.

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Title: Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial.
Authors: Heinonen S; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. sini.heinonen@helsinki.fi.; Department of Internal Medicine and Rehabilitation, Helsinki University Hospital, Helsinki, Finland. sini.heinonen@helsinki.fi., Karppinen JE; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. jari.karppinen@helsinki.fi., Saarinen T; Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Abdominal Center, Helsinki, Finland., Groop PH; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland., Juuti A; Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Abdominal Center, Helsinki, Finland., Holst JJ; The NovoNordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences, Endocrinology and Metabolism, University of Copenhagen, Copenhagen, Denmark., Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; HealthyWeightHub, Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Source: International journal of obesity (2005) [Int J Obes (Lond)] 2026 May; Vol. 50 (5), pp. 1015-1026. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101256108 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5497 (Electronic) Linking ISSN: 03070565 NLM ISO Abbreviation: Int J Obes (Lond) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Heinonen+S%22">Heinonen S</searchLink>; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. sini.heinonen@helsinki.fi.; Department of Internal Medicine and Rehabilitation, Helsinki University Hospital, Helsinki, Finland. sini.heinonen@helsinki.fi.<br /><searchLink fieldCode="AU" term="%22Karppinen+JE%22">Karppinen JE</searchLink>; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. jari.karppinen@helsinki.fi.<br /><searchLink fieldCode="AU" term="%22Saarinen+T%22">Saarinen T</searchLink>; Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Abdominal Center, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Groop+PH%22">Groop PH</searchLink>; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Juuti+A%22">Juuti A</searchLink>; Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Abdominal Center, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Holst+JJ%22">Holst JJ</searchLink>; The NovoNordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences, Endocrinology and Metabolism, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Pietiläinen+KH%22">Pietiläinen KH</searchLink>; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; HealthyWeightHub, Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
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  Data: <searchLink fieldCode="JN" term="%22101256108%22">International journal of obesity (2005)</searchLink> [Int J Obes (Lond)] 2026 May; Vol. 50 (5), pp. 1015-1026. <i>Date of Electronic Publication: </i>2026 Jan 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101256108 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5497 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203070565%22">03070565 </searchLink><i>NLM ISO Abbreviation: </i>Int J Obes (Lond) <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41366-025-02000-3
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              Text: 2026 May
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