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Plasma extracellular vesicles and phosphorylated tau 181 as early biomarkers of cognitive impairment in Alzheimer's dementia.

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Title: Plasma extracellular vesicles and phosphorylated tau 181 as early biomarkers of cognitive impairment in Alzheimer's dementia.
Authors: Brembati V; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy., Crescenti D; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy. dcrescenti@fatebenefratelli.eu., Geviti A; Service of Statistics, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy., Rossini E; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy., Cazzaniga FA; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy., Moda F; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, 20133, Italy., Zanier ER; Department of Acute Brain and Cardiovascular Injury, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy., Guerrera G; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, 00179, Italy., Battistini L; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, 00179, Italy., Baiardi S; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40139, Italy., Mandelli A; Clinical Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, 20132, Italy., Furlan R; Clinical Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, 20132, Italy.; Vita-Salute San Raffaele University, Milan, 20132, Italy., Verde F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, 20149, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università Degli Studi Di Milano, Milan, 20122, Italy., Nacmias B; IRCCS Fondazione Don Carlo Gnocchi, Florence, 50143, Italy.; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, 50139, Italy., Elia CA; Neuroscience Institute, Consiglio Nazionale Ricerche, URT C/O IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.; Lab of Pharmacology and Brain Pathology, IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy., Malosio ML; Neuroscience Institute, Consiglio Nazionale Ricerche, URT C/O IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.; Lab of Pharmacology and Brain Pathology, IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy., Imarisio A; Neurogenetics Research Centre, IRCCS Mondino Foundation, Pavia, 27100, Italy.; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Guerini FR; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, 20148, Italy., Fenoglio C; IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy.; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Di Fonzo A; IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy., Biscetti L; Section of Neurology, Italian National Research Center On Aging (IRCCS INRCA), Ancona, 60121, Italy., Squillario M; LISCOMP Laboratory, IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy., Berra S; LISCOMP Laboratory, IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy., Miraglia F; Brain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, 00166, Italy., Rossini PM; Department of Neuroscience & Neurorehabilitation, IRCCS San Raffaele Roma, Rome, 00163, Italy., Marra C; Neurology Unit, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, 00168, Italy., Vanacore N; National Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, 00161, Italy., Redolfi A; Laboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy., Perani D; Vita-Salute San Raffaele University, Milan, 20132, Italy.; Nuclear Medicine Unit, IRCCS Ospedale San Raffaele, Milan, 20132, Italy., Spadin P; Associazione Italiana Malattia Di Alzheimer - AIMA, Milan, 20149, Italy., Cotelli M; Neuropsychology Unit, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy., Cappa S; University Institute of Advanced Studies (IUSS-Pavia), Pavia, 27100, Italy., Caraglia N; Memory Clinic, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, 00168, Italy., Vecchio F; Brain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Rome, 00166, Italy., Tiraboschi P; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy., Piras F; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, 00179, Italy., Frisoni GB; Geneva Memory Center, Geneva University Hospitals, Geneva, 1205, Switzerland., Muscio C; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.; ASST Bergamo Ovest, Bergamo, Italy., Lodi R; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40139, Italy., Parchi P; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40139, Italy., Tagliavini F; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy., Valente EM; Neurogenetics Research Centre, IRCCS Mondino Foundation, Pavia, 27100, Italy.; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Forloni G; Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy. rghidoni@fatebenefratelli.eu.
Corporate Authors: INTERCEPTOR Network, Network-AD project, Biomarker Italian Team
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Jan 06; Vol. 18 (1), pp. 3. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma extracellular vesicles and phosphorylated tau 181 as early biomarkers of cognitive impairment in Alzheimer's dementia.
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  Data: <searchLink fieldCode="AU" term="%22Brembati+V%22">Brembati V</searchLink>; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy.<br /><searchLink fieldCode="AU" term="%22Crescenti+D%22">Crescenti D</searchLink>; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy. dcrescenti@fatebenefratelli.eu.<br /><searchLink fieldCode="AU" term="%22Geviti+A%22">Geviti A</searchLink>; Service of Statistics, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy.<br /><searchLink fieldCode="AU" term="%22Rossini+E%22">Rossini E</searchLink>; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, 25125, Italy.<br /><searchLink fieldCode="AU" term="%22Cazzaniga+FA%22">Cazzaniga FA</searchLink>; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Moda+F%22">Moda F</searchLink>; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Zanier+ER%22">Zanier ER</searchLink>; Department of Acute Brain and Cardiovascular Injury, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy.<br /><searchLink fieldCode="AU" term="%22Guerrera+G%22">Guerrera G</searchLink>; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, 00179, Italy.<br /><searchLink fieldCode="AU" term="%22Battistini+L%22">Battistini L</searchLink>; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, 00179, Italy.<br /><searchLink fieldCode="AU" term="%22Baiardi+S%22">Baiardi S</searchLink>; IRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40139, Italy.<br /><searchLink fieldCode="AU" term="%22Mandelli+A%22">Mandelli A</searchLink>; 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Neuroscience Institute, Consiglio Nazionale Ricerche, URT C/O IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.; Lab of Pharmacology and Brain Pathology, IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Malosio+ML%22">Malosio ML</searchLink>; Neuroscience Institute, Consiglio Nazionale Ricerche, URT C/O IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.; Lab of Pharmacology and Brain Pathology, IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.<br /><searchLink fieldCode="AU" term="%22Imarisio+A%22">Imarisio A</searchLink>; Neurogenetics Research Centre, IRCCS Mondino Foundation, Pavia, 27100, Italy.; Department of Molecular Medicine, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Guerini+FR%22">Guerini FR</searchLink>; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, 20148, Italy.<br /><searchLink fieldCode="AU" term="%22Fenoglio+C%22">Fenoglio C</searchLink>; IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, 20122, Italy.; 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