Cyclodextrin-based delivery of Annexin A1 mimetic Ac2-26 enhances anti-inflammatory effect and prevents dengue-induced lethality combined with antiviral therapy.

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Title: Cyclodextrin-based delivery of Annexin A1 mimetic Ac2-26 enhances anti-inflammatory effect and prevents dengue-induced lethality combined with antiviral therapy.
Authors: Martins JR; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Batista VL; Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Ramos LG; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Queiroz-Junior CM; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., da Fonseca TCM; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Dias ASL; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Silva LS; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., da Silva Santos FR; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., de Castro Santos AL; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Lula IS; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Rocha FEO; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Pereira JAB; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Lara ES; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil., Souza TML; Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, Brazil., Sousa LP; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil., Teixeira MM; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Guimarães PPG; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Costa VV; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Source: British journal of pharmacology [Br J Pharmacol] 2026 May; Vol. 183 (10), pp. 2341-2359. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cyclodextrin-based delivery of Annexin A1 mimetic Ac2-26 enhances anti-inflammatory effect and prevents dengue-induced lethality combined with antiviral therapy.
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  Data: <searchLink fieldCode="AU" term="%22Martins+JR%22">Martins JR</searchLink>; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Batista+VL%22">Batista VL</searchLink>; Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Ramos+LG%22">Ramos LG</searchLink>; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Queiroz-Junior+CM%22">Queiroz-Junior CM</searchLink>; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Fonseca+TCM%22">da Fonseca TCM</searchLink>; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+ASL%22">Dias ASL</searchLink>; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+LS%22">Silva LS</searchLink>; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Santos+FR%22">da Silva Santos FR</searchLink>; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Castro+Santos+AL%22">de Castro Santos AL</searchLink>; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Lula+IS%22">Lula IS</searchLink>; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Rocha+FEO%22">Rocha FEO</searchLink>; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+JAB%22">Pereira JAB</searchLink>; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Lara+ES%22">Lara ES</searchLink>; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+TML%22">Souza TML</searchLink>; Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.; National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+LP%22">Sousa LP</searchLink>; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Teixeira+MM%22">Teixeira MM</searchLink>; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Guimarães+PPG%22">Guimarães PPG</searchLink>; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+VV%22">Costa VV</searchLink>; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2026 May; Vol. 183 (10), pp. 2341-2359. <i>Date of Electronic Publication: </i>2026 Jan 06.
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