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Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

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Title: Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.
Authors: Zhou DD; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia. Electronic address: deborah.zhou@sydney.edu.au., Lord SJ; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia., Lin FP; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia., Cooper WA; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, 19 NSW Health Pathology, Missenden Rd, Camperdown, NSW 2050, Australia; University of Sydney Faculty of Medicine and Health, Australia; Western Sydney University School of Medicine, Australia., Zaheed M; Prince of Wales Hereditary Cancer Centre, Bright Building, 64-66 High Street, Randwick, NSW 2031, Australia., Simes RJ; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia., John T; Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, Australia., Lee CK; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.
Source: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2026 Feb; Vol. 212, pp. 108891. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8800805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8332 (Electronic) Linking ISSN: 01695002 NLM ISO Abbreviation: Lung Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+DD%22">Zhou DD</searchLink>; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia. Electronic address: deborah.zhou@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22Lord+SJ%22">Lord SJ</searchLink>; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Lin+FP%22">Lin FP</searchLink>; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Cooper+WA%22">Cooper WA</searchLink>; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, 19 NSW Health Pathology, Missenden Rd, Camperdown, NSW 2050, Australia; University of Sydney Faculty of Medicine and Health, Australia; Western Sydney University School of Medicine, Australia.<br /><searchLink fieldCode="AU" term="%22Zaheed+M%22">Zaheed M</searchLink>; Prince of Wales Hereditary Cancer Centre, Bright Building, 64-66 High Street, Randwick, NSW 2031, Australia.<br /><searchLink fieldCode="AU" term="%22Simes+RJ%22">Simes RJ</searchLink>; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.<br /><searchLink fieldCode="AU" term="%22John+T%22">John T</searchLink>; Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+CK%22">Lee CK</searchLink>; NHMRC Clinical Trials Centre, University of Sydney, Level 6, Lifehouse, 119-143 Missenden Rd, Camperdown, NSW 2050, Australia.
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  Data: <searchLink fieldCode="JN" term="%228800805%22">Lung cancer (Amsterdam, Netherlands)</searchLink> [Lung Cancer] 2026 Feb; Vol. 212, pp. 108891. <i>Date of Electronic Publication: </i>2025 Dec 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers%22">Elsevier Scientific Publishers </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>8800805 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-8332 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201695002%22">01695002 </searchLink><i>NLM ISO Abbreviation: </i>Lung Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.lungcan.2025.108891
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      – Code: eng
        Text: English
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      – TitleFull: Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.
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              Text: 2026 Feb
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              Y: 2026
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