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ipRGC properties prevent light from shifting the SCN clock during daytime.

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Title: ipRGC properties prevent light from shifting the SCN clock during daytime.
Authors: Komal R; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. ruchi.komal@nih.gov., Beier C; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA., Nath A; Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA., Grimes WN; Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA., Wang H; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA., Berry M; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA., Gao C; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA., Yang S; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA., Thurman M; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA., Ostermeyer GP; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA., Ball J; Retinal Neurophysiology Unit, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA., Li W; Retinal Neurophysiology Unit, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.; SANS Institute for Neuroscience and Vision Research, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Brown RL; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA., Penzo M; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA., Sivyer B; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA., Diamond JS; Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA., Zhao H; Department of Biology, Johns Hopkins University, Baltimore, MD, USA., Hattar S; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. samer.hattar@nih.gov.
Source: Nature [Nature] 2026 Feb; Vol. 650 (8103), pp. 942-950. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Komal+R%22">Komal R</searchLink>; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. ruchi.komal@nih.gov.<br /><searchLink fieldCode="AU" term="%22Beier+C%22">Beier C</searchLink>; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nath+A%22">Nath A</searchLink>; Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Grimes+WN%22">Grimes WN</searchLink>; Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Berry+M%22">Berry M</searchLink>; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Thurman+M%22">Thurman M</searchLink>; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ostermeyer+GP%22">Ostermeyer GP</searchLink>; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ball+J%22">Ball J</searchLink>; Retinal Neurophysiology Unit, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Retinal Neurophysiology Unit, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.; SANS Institute for Neuroscience and Vision Research, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Brown+RL%22">Brown RL</searchLink>; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.<br /><searchLink fieldCode="AU" term="%22Penzo+M%22">Penzo M</searchLink>; Section on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sivyer+B%22">Sivyer B</searchLink>; Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Diamond+JS%22">Diamond JS</searchLink>; Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Department of Biology, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hattar+S%22">Hattar S</searchLink>; Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. samer.hattar@nih.gov.
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