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RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity.

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Title: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity.
Authors: Dmytrenko O; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Yuan B; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany., Crosby KT; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Krebel M; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Chen X; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Nowak JS; Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland., Chramiec-Głąbik A; Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland., Filani B; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Gribling-Burrer AS; Architecture et Réactivitié de l'ARN, Université de Strasbourg, CNRS, Institute of Molecular and Cellular Biology (IBMC), University of Strasbourg, Strasbourg, France., van der Toorn W; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.; Project Groups, Robert Koch Institute, Berlin, Germany., von Kleist M; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.; Project Groups, Robert Koch Institute, Berlin, Germany., Achmedov T; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Smyth RP; Architecture et Réactivitié de l'ARN, Université de Strasbourg, CNRS, Institute of Molecular and Cellular Biology (IBMC), University of Strasbourg, Strasbourg, France., Glatt S; Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland.; University of Veterinary Medicine, Vienna, Austria., Bravo JPK; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Heinz DW; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. dirk.heinz@helmholtz-hzi.de., Jackson RN; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA. ryan.jackson@usu.edu., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@helmholtz-hiri.de.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@helmholtz-hiri.de.
Source: Nature [Nature] 2026 Jan; Vol. 649 (8099), pp. 1312-1321. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity.
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  Data: <searchLink fieldCode="AU" term="%22Dmytrenko+O%22">Dmytrenko O</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Yuan+B%22">Yuan B</searchLink>; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Crosby+KT%22">Crosby KT</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA.<br /><searchLink fieldCode="AU" term="%22Krebel+M%22">Krebel M</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nowak+JS%22">Nowak JS</searchLink>; Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Chramiec-Głąbik+A%22">Chramiec-Głąbik A</searchLink>; Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Filani+B%22">Filani B</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA.<br /><searchLink fieldCode="AU" term="%22Gribling-Burrer+AS%22">Gribling-Burrer AS</searchLink>; Architecture et Réactivitié de l'ARN, Université de Strasbourg, CNRS, Institute of Molecular and Cellular Biology (IBMC), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22van+der+Toorn+W%22">van der Toorn W</searchLink>; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.; Project Groups, Robert Koch Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22von+Kleist+M%22">von Kleist M</searchLink>; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.; Project Groups, Robert Koch Institute, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Achmedov+T%22">Achmedov T</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Smyth+RP%22">Smyth RP</searchLink>; Architecture et Réactivitié de l'ARN, Université de Strasbourg, CNRS, Institute of Molecular and Cellular Biology (IBMC), University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Glatt+S%22">Glatt S</searchLink>; Malopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland.; University of Veterinary Medicine, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Bravo+JPK%22">Bravo JPK</searchLink>; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.<br /><searchLink fieldCode="AU" term="%22Heinz+DW%22">Heinz DW</searchLink>; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. dirk.heinz@helmholtz-hzi.de.<br /><searchLink fieldCode="AU" term="%22Jackson+RN%22">Jackson RN</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA. ryan.jackson@usu.edu.<br /><searchLink fieldCode="AU" term="%22Beisel+CL%22">Beisel CL</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@helmholtz-hiri.de.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@helmholtz-hiri.de.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jan; Vol. 649 (8099), pp. 1312-1321. <i>Date of Electronic Publication: </i>2026 Jan 07.
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