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Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels.

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Title: Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels.
Authors: Piva M; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil., Yaekashi KM; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil., Pereira TGO; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil., Bertozzi MM; Departament of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina, Paraná, Brazil., Pinho-Ribeiro FA; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Division of Dermatology, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO, USA., Calixto-Campos C; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil., Camilios-Neto D; Department of Biochemistry and Biotechnology, Centre of Exact Sciences, Londrina State University, Londrina, PR, 86057-970, Brazil., Borghi SM; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Paraná, Brazil., Zarpelon-Schutz AC; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Federal University of Parana, Campus Toledo, Toledo, Paraná, 85919-899, Brazil., Fattori V; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Departament of Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Karp Research Building, Boston, MA, USA., Casagrande R; Departament of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina, Paraná, Brazil., Verri WA Jr; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil. waldiceujr@yahoo.com.br.
Source: Inflammopharmacology [Inflammopharmacology] 2026 Feb; Vol. 34 (2), pp. 1213-1232. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE
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  Data: Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels.
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  Data: <searchLink fieldCode="AU" term="%22Piva+M%22">Piva M</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Yaekashi+KM%22">Yaekashi KM</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+TGO%22">Pereira TGO</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Bertozzi+MM%22">Bertozzi MM</searchLink>; Departament of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina, Paraná, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinho-Ribeiro+FA%22">Pinho-Ribeiro FA</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Division of Dermatology, Department of Medicine, Washington University School of Medicine in St. Louis, Saint Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Calixto-Campos+C%22">Calixto-Campos C</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Camilios-Neto+D%22">Camilios-Neto D</searchLink>; Department of Biochemistry and Biotechnology, Centre of Exact Sciences, Londrina State University, Londrina, PR, 86057-970, Brazil.<br /><searchLink fieldCode="AU" term="%22Borghi+SM%22">Borghi SM</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Center for Research in Health Sciences, University of Northern Paraná, Londrina, Paraná, Brazil.<br /><searchLink fieldCode="AU" term="%22Zarpelon-Schutz+AC%22">Zarpelon-Schutz AC</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Federal University of Parana, Campus Toledo, Toledo, Paraná, 85919-899, Brazil.<br /><searchLink fieldCode="AU" term="%22Fattori+V%22">Fattori V</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil.; Departament of Vascular Biology Program, Department of Surgery, Boston Children's Hospital-Harvard Medical School, Karp Research Building, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Casagrande+R%22">Casagrande R</searchLink>; Departament of Pharmaceutical Sciences, Center of Health Sciences, Londrina State University, Londrina, Paraná, Brazil.<br /><searchLink fieldCode="AU" term="%22Verri+WA+Jr%22">Verri WA Jr</searchLink>; Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, Londrina State University, Rod. Celso Garcia Cid Pr 445 KM 380, P.O. box 10.011, Londrina, Paraná, 86057-970, Brazil. waldiceujr@yahoo.com.br.
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  Data: <searchLink fieldCode="JN" term="%229112626%22">Inflammopharmacology</searchLink> [Inflammopharmacology] 2026 Feb; Vol. 34 (2), pp. 1213-1232. <i>Date of Electronic Publication: </i>2026 Jan 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Birkhäuser%22">Birkhäuser </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9112626 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1568-5608 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209254692%22">09254692 </searchLink><i>NLM ISO Abbreviation: </i>Inflammopharmacology <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10787-025-02099-w
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        Text: English
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