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Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.

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Title: Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.
Authors: Fu X; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Liu W; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Demyanenko Y; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Kamel W; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Ravi RT; The Rosalind Franklin Institute, Harwell, UK., Ruscica V; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Noerenberg M; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Yin X; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Jiang Y; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Fan CH; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Kowalczyk KM; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Kitano E; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK., Morgan J; Department of Chemistry, University of Oxford, Oxford, UK., Aldridge S; Department of Chemistry, University of Oxford, Oxford, UK., Dumoux M; The Rosalind Franklin Institute, Harwell, UK., Castello A; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Mohammed S; The Rosalind Franklin Institute, Harwell, UK. Shabaz.Mohammed@chem.ox.ac.uk.; Department of Chemistry, University of Oxford, Oxford, UK. Shabaz.Mohammed@chem.ox.ac.uk.; Department of Biochemistry, University of Oxford, Oxford, UK. Shabaz.Mohammed@chem.ox.ac.uk., Davis BG; The Rosalind Franklin Institute, Harwell, UK. Ben.Davis@rfi.ac.uk.; Department of Pharmacology, University of Oxford, Oxford, UK. Ben.Davis@rfi.ac.uk.; Department of Chemistry, University of Oxford, Oxford, UK. Ben.Davis@rfi.ac.uk.
Source: Nature chemistry [Nat Chem] 2026 Mar; Vol. 18 (3), pp. 457-472. Date of Electronic Publication: 2026 Jan 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE
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  Data: Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.
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  Data: <searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Demyanenko+Y%22">Demyanenko Y</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kamel+W%22">Kamel W</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ravi+RT%22">Ravi RT</searchLink>; The Rosalind Franklin Institute, Harwell, UK.<br /><searchLink fieldCode="AU" term="%22Ruscica+V%22">Ruscica V</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Noerenberg+M%22">Noerenberg M</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fan+CH%22">Fan CH</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kowalczyk+KM%22">Kowalczyk KM</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kitano+E%22">Kitano E</searchLink>; The Rosalind Franklin Institute, Harwell, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Morgan+J%22">Morgan J</searchLink>; Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Aldridge+S%22">Aldridge S</searchLink>; Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dumoux+M%22">Dumoux M</searchLink>; The Rosalind Franklin Institute, Harwell, UK.<br /><searchLink fieldCode="AU" term="%22Castello+A%22">Castello A</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Mohammed+S%22">Mohammed S</searchLink>; The Rosalind Franklin Institute, Harwell, UK. Shabaz.Mohammed@chem.ox.ac.uk.; Department of Chemistry, University of Oxford, Oxford, UK. Shabaz.Mohammed@chem.ox.ac.uk.; Department of Biochemistry, University of Oxford, Oxford, UK. Shabaz.Mohammed@chem.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Davis+BG%22">Davis BG</searchLink>; The Rosalind Franklin Institute, Harwell, UK. Ben.Davis@rfi.ac.uk.; Department of Pharmacology, University of Oxford, Oxford, UK. Ben.Davis@rfi.ac.uk.; Department of Chemistry, University of Oxford, Oxford, UK. Ben.Davis@rfi.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101499734%22">Nature chemistry</searchLink> [Nat Chem] 2026 Mar; Vol. 18 (3), pp. 457-472. <i>Date of Electronic Publication: </i>2026 Jan 07.
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