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Urea cycle modulation by combined SGLT2 inhibitors and metformin.

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Title: Urea cycle modulation by combined SGLT2 inhibitors and metformin.
Authors: Harada M; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Adam J; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Han S; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Shi M; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Ge J; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Lintelmann J; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Cecil A; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Zukunft S; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Prehn C; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Witting M; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Analytical Food Chemistry, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Scheerer MF; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Neschen S; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Irmler M; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Beckers J; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences, TUM, Freising, Germany., Adamski J; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Teupser D; Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany., Linkohr B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., de Angelis MH; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences, TUM, Freising, Germany., Peters A; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute for Medical Information Processing, Biometry, and Epidemiology, Pettenkofer School of Public Health, Ludwig Maximilian University of Munich (LMU), Munich, Germany., Wang-Sattler R; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. rui.wang-sattler@helmholtz-munich.de.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany. rui.wang-sattler@helmholtz-munich.de.
Source: BMC medicine [BMC Med] 2026 Jan 08; Vol. 24 (1), pp. 55. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Urea cycle modulation by combined SGLT2 inhibitors and metformin.
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  Data: <searchLink fieldCode="AU" term="%22Harada+M%22">Harada M</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Adam+J%22">Adam J</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ge+J%22">Ge J</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lintelmann+J%22">Lintelmann J</searchLink>; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cecil+A%22">Cecil A</searchLink>; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zukunft+S%22">Zukunft S</searchLink>; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Prehn+C%22">Prehn C</searchLink>; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Witting+M%22">Witting M</searchLink>; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Analytical Food Chemistry, TUM School of Life Sciences, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Scheerer+MF%22">Scheerer MF</searchLink>; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Neschen+S%22">Neschen S</searchLink>; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Irmler+M%22">Irmler M</searchLink>; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Beckers+J%22">Beckers J</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences, TUM, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Adamski+J%22">Adamski J</searchLink>; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Teupser+D%22">Teupser D</searchLink>; Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Linkohr+B%22">Linkohr B</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gieger+C%22">Gieger C</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22de+Angelis+MH%22">de Angelis MH</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences, TUM, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+A%22">Peters A</searchLink>; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute for Medical Information Processing, Biometry, and Epidemiology, Pettenkofer School of Public Health, Ludwig Maximilian University of Munich (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wang-Sattler+R%22">Wang-Sattler R</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. rui.wang-sattler@helmholtz-munich.de.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany. rui.wang-sattler@helmholtz-munich.de.
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  Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2026 Jan 08; Vol. 24 (1), pp. 55. <i>Date of Electronic Publication: </i>2026 Jan 08.
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