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Compounds Reducing Human Sperm Motility as Potential Nonhormonal Contraceptives Identified Using a High-Throughput Phenotypic Screening Platform.

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Title: Compounds Reducing Human Sperm Motility as Potential Nonhormonal Contraceptives Identified Using a High-Throughput Phenotypic Screening Platform.
Authors: Richardson A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Gruber FS; National Phenotypic Screening Centre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Day DP; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Edwards D; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Georgiou I; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Johnston ZC; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K., Joji H; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Martins da Silva S; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K., Myles R; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K., Norcross NR; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Swedlow JR; Divisions of Computational Biology and Molecular, Cellular and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.; National Phenotypic Screening Centre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Wilson C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K., Barratt CLR; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K., Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.
Source: ACS omega [ACS Omega] 2025 Nov 27; Vol. 10 (48), pp. 59121-59134. Date of Electronic Publication: 2025 Nov 27 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Richardson+A%22">Richardson A</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Gruber+FS%22">Gruber FS</searchLink>; National Phenotypic Screening Centre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Day+DP%22">Day DP</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Edwards+D%22">Edwards D</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Georgiou+I%22">Georgiou I</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Johnston+ZC%22">Johnston ZC</searchLink>; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K.<br /><searchLink fieldCode="AU" term="%22Joji+H%22">Joji H</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Martins+da+Silva+S%22">Martins da Silva S</searchLink>; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K.<br /><searchLink fieldCode="AU" term="%22Myles+R%22">Myles R</searchLink>; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K.<br /><searchLink fieldCode="AU" term="%22Norcross+NR%22">Norcross NR</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Swedlow+JR%22">Swedlow JR</searchLink>; Divisions of Computational Biology and Molecular, Cellular and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.; National Phenotypic Screening Centre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Wilson+C%22">Wilson C</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Barratt+CLR%22">Barratt CLR</searchLink>; Reproductive Medicine Research Group, Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, U.K.<br /><searchLink fieldCode="AU" term="%22Gilbert+IH%22">Gilbert IH</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, U.K.
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