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Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.

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Title: Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
Authors: Georgiou I; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Robinson C; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., O'Byrne SN; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Matsuda A; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.; Doctoral School of Exact and Natural Sciences, Jagiellonian University Krakow Poland., Grygier P; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.; Doctoral School of Exact and Natural Sciences, Jagiellonian University Krakow Poland., Smith CD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., O'Neill S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Ahmad SA; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Norval S; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Post JM; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Groenewold M; Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center Leiden The Netherlands., Urakova N; Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center Leiden The Netherlands.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) Wellcome Genome Campus, Hinxton Cambridge CB10 1SD UK., Wanningen P; Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center Leiden The Netherlands., Kresik L; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl., Plewka J; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University Gronostajowa 2 30-387 Krakow Poland., Delpal A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) Wellcome Genome Campus, Hinxton Cambridge CB10 1SD UK., See K; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Eadsforth T; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Wierzbicka K; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl., Decroly E; Aix Marseille Université, CNRS AFMB UMR 7257 Marseille France., Saikatendu KS; Takeda Development Center Americas Inc 500 Kendall St Cambridge MA 02142 USA., Chang E; Takeda Development Center Americas Inc 500 Kendall St Cambridge MA 02142 USA., Snijder EJ; Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center Leiden The Netherlands., Pyrć K; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl., Czarna A; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl., Scott DE; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk., Gilbert IH; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.
Source: RSC medicinal chemistry [RSC Med Chem] 2026 Jan 06. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem
Database: MEDLINE Ultimate
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  Data: Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase.
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  Data: <searchLink fieldCode="AU" term="%22Georgiou+I%22">Georgiou I</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Robinson+C%22">Robinson C</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22O'Byrne+SN%22">O'Byrne SN</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Matsuda+A%22">Matsuda A</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.; Doctoral School of Exact and Natural Sciences, Jagiellonian University Krakow Poland.<br /><searchLink fieldCode="AU" term="%22Grygier+P%22">Grygier P</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.; Doctoral School of Exact and Natural Sciences, Jagiellonian University Krakow Poland.<br /><searchLink fieldCode="AU" term="%22Smith+CD%22">Smith CD</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22O'Neill+S%22">O'Neill S</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Ahmad+SA%22">Ahmad SA</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Norval+S%22">Norval S</searchLink>; 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Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center Leiden The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kresik+L%22">Kresik L</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.<br /><searchLink fieldCode="AU" term="%22Plewka+J%22">Plewka J</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University Gronostajowa 2 30-387 Krakow Poland.<br /><searchLink fieldCode="AU" term="%22Delpal+A%22">Delpal A</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) Wellcome Genome Campus, Hinxton Cambridge CB10 1SD UK.<br /><searchLink fieldCode="AU" term="%22See+K%22">See K</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Eadsforth+T%22">Eadsforth T</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Wierzbicka+K%22">Wierzbicka K</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.<br /><searchLink fieldCode="AU" term="%22Decroly+E%22">Decroly E</searchLink>; Aix Marseille Université, CNRS AFMB UMR 7257 Marseille France.<br /><searchLink fieldCode="AU" term="%22Saikatendu+KS%22">Saikatendu KS</searchLink>; Takeda Development Center Americas Inc 500 Kendall St Cambridge MA 02142 USA.<br /><searchLink fieldCode="AU" term="%22Chang+E%22">Chang E</searchLink>; Takeda Development Center Americas Inc 500 Kendall St Cambridge MA 02142 USA.<br /><searchLink fieldCode="AU" term="%22Snijder+EJ%22">Snijder EJ</searchLink>; Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center Leiden The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pyrć+K%22">Pyrć K</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.<br /><searchLink fieldCode="AU" term="%22Czarna+A%22">Czarna A</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University Gronostajowa 7a 30-387 Krakow Poland anna1.czarna@uj.edu.pl.<br /><searchLink fieldCode="AU" term="%22Scott+DE%22">Scott DE</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Gilbert+IH%22">Gilbert IH</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee Dundee DD1 5EH UK dscott004@dundee.ac.uk ian.h.gilbert.@dundee.ac.uk.
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