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Advancing patient stratification in major depressive disorder: Evaluation of clinical staging and machine learning prediction models based on real-world data.

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Title: Advancing patient stratification in major depressive disorder: Evaluation of clinical staging and machine learning prediction models based on real-world data.
Authors: Reneses B; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain. Electronic address: blanca@reneses.es., García-Huéscar M; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain., Argudo I; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Machin M; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Bravo G; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERCV ((Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares), Spain., Saz M; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain., Zamarro ML; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Díaz-Marsá M; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain., Fraguas D; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.
Source: Journal of affective disorders [J Affect Disord] 2026 May 01; Vol. 400, pp. 121128. Date of Electronic Publication: 2026 Jan 06.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Advancing patient stratification in major depressive disorder: Evaluation of clinical staging and machine learning prediction models based on real-world data.
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  Data: <searchLink fieldCode="AU" term="%22Reneses+B%22">Reneses B</searchLink>; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain. Electronic address: blanca@reneses.es.<br /><searchLink fieldCode="AU" term="%22García-Huéscar+M%22">García-Huéscar M</searchLink>; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Argudo+I%22">Argudo I</searchLink>; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Machin+M%22">Machin M</searchLink>; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bravo+G%22">Bravo G</searchLink>; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERCV ((Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares), Spain.<br /><searchLink fieldCode="AU" term="%22Saz+M%22">Saz M</searchLink>; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zamarro+ML%22">Zamarro ML</searchLink>; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz-Marsá+M%22">Díaz-Marsá M</searchLink>; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fraguas+D%22">Fraguas D</searchLink>; Institute of biomedical research IdISSC, Hospital Clínico San Carlos, Madrid, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Complutense University, School of Medicine (UCM), Madrid, Spain; Institute of Psychiatry and Mental Health, Hospital Clínico San Carlos, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%227906073%22">Journal of affective disorders</searchLink> [J Affect Disord] 2026 May 01; Vol. 400, pp. 121128. <i>Date of Electronic Publication: </i>2026 Jan 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2FNorth-Holland+Biomedical+Press%22">Elsevier/North-Holland Biomedical Press </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7906073 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-2517 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201650327%22">01650327 </searchLink><i>NLM ISO Abbreviation: </i>J Affect Disord <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jad.2025.121128
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        Text: English
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              Text: 2026 May 01
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