Design and rationale of the GUARD-OAC: A randomized controlled trial evaluating proton pump inhibitor cotherapy for gastrointestinal protection in patients requiring direct oral anticoagulants.
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| Title: | Design and rationale of the GUARD-OAC: A randomized controlled trial evaluating proton pump inhibitor cotherapy for gastrointestinal protection in patients requiring direct oral anticoagulants. |
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| Authors: | Ahn HJ; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Lee SR; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Kwon S; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea., Rhee TM; Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea., Lee YS; Department of Cardiology, Daegu Catholic University Medical Center, Daegu, Republic of Korea., Han SJ; Department of Internal Medicine, College of Medicine, Hallym University, Anyang, Republic of Korea., Kang KW; Department of Internal Medicine, Division of Cardiology, Chung-Ang University Hospital, College of Medicine, Seoul, Republic of Korea., Shim J; Department of Internal Medicine, Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea., Yu HT; Department of Internal Medicine, Division of Cardiology, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea., Oh IY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Cardiology, Cardiovascular Centre, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Park HS; Department of Internal Medicine, Division of Cardiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea., Park JK; Department of Internal Medicine, Division of Cardiology, Hanyang University Seoul Hospital, Seoul, Republic of Korea., Jang SW; Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, Division of Cardiology, The Catholic University of Korea, Seoul, Republic of Korea., Lee SH; Department of Internal Medicine, Kangbuk Samsung Hospital, Division of Cardiology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea., Roh SY; Department of Internal Medicine, Division of Cardiology, Korea University Medicine Guro hospital, Seoul, Republic of Korea., Chun KJ; Department of Internal Medicine, Division of Cardiology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Republic of Korea., Park HW; Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea., Lee KY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Division of Cardiology, Korea University Medicine Guro hospital, Seoul, Republic of Korea., Oh S; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Choi EK; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: choiek17@snu.ac.kr. |
| Corporate Authors: | GUARD-OAC Trial Investigators |
| Source: | American heart journal [Am Heart J] 2026 May; Vol. 295, pp. 107341. Date of Electronic Publication: 2026 Jan 06. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41506417 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Design and rationale of the GUARD-OAC: A randomized controlled trial evaluating proton pump inhibitor cotherapy for gastrointestinal protection in patients requiring direct oral anticoagulants. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ahn+HJ%22">Ahn HJ</searchLink>; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SR%22">Lee SR</searchLink>; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+S%22">Kwon S</searchLink>; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Rhee+TM%22">Rhee TM</searchLink>; Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Cardiology, Daegu Catholic University Medical Center, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+SJ%22">Han SJ</searchLink>; Department of Internal Medicine, College of Medicine, Hallym University, Anyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+KW%22">Kang KW</searchLink>; Department of Internal Medicine, Division of Cardiology, Chung-Ang University Hospital, College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shim+J%22">Shim J</searchLink>; Department of Internal Medicine, Division of Cardiology, Korea University College of Medicine and Korea University Anam Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yu+HT%22">Yu HT</searchLink>; Department of Internal Medicine, Division of Cardiology, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+IY%22">Oh IY</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Cardiology, Cardiovascular Centre, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+HS%22">Park HS</searchLink>; Department of Internal Medicine, Division of Cardiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+JK%22">Park JK</searchLink>; Department of Internal Medicine, Division of Cardiology, Hanyang University Seoul Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+SW%22">Jang SW</searchLink>; Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, Division of Cardiology, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Department of Internal Medicine, Kangbuk Samsung Hospital, Division of Cardiology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Roh+SY%22">Roh SY</searchLink>; Department of Internal Medicine, Division of Cardiology, Korea University Medicine Guro hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chun+KJ%22">Chun KJ</searchLink>; Department of Internal Medicine, Division of Cardiology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+HW%22">Park HW</searchLink>; Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+KY%22">Lee KY</searchLink>; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Division of Cardiology, Korea University Medicine Guro hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+EK%22">Choi EK</searchLink>; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: choiek17@snu.ac.kr. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22GUARD-OAC+Trial+Investigators%22">GUARD-OAC Trial Investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220370465%22">American heart journal</searchLink> [Am Heart J] 2026 May; Vol. 295, pp. 107341. <i>Date of Electronic Publication: </i>2026 Jan 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370465 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6744 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200028703%22">00028703 </searchLink><i>NLM ISO Abbreviation: </i>Am Heart J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41506417 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ahj.2026.107341 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107341 Titles: – TitleFull: Design and rationale of the GUARD-OAC: A randomized controlled trial evaluating proton pump inhibitor cotherapy for gastrointestinal protection in patients requiring direct oral anticoagulants. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ahn HJ – PersonEntity: Name: NameFull: Lee SR – PersonEntity: Name: NameFull: Kwon S – PersonEntity: Name: NameFull: Rhee TM – PersonEntity: Name: NameFull: Lee YS – PersonEntity: Name: NameFull: Han SJ – PersonEntity: Name: NameFull: Kang KW – PersonEntity: Name: NameFull: Shim J – PersonEntity: Name: NameFull: Yu HT – PersonEntity: Name: NameFull: Oh IY – PersonEntity: Name: NameFull: Park HS – PersonEntity: Name: NameFull: Park JK – PersonEntity: Name: NameFull: Jang SW – PersonEntity: Name: NameFull: Lee SH – PersonEntity: Name: NameFull: Roh SY – PersonEntity: Name: NameFull: Chun KJ – PersonEntity: Name: NameFull: Park HW – PersonEntity: Name: NameFull: Lee KY – PersonEntity: Name: NameFull: Oh S – PersonEntity: Name: NameFull: Choi EK IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1097-6744 Numbering: – Type: volume Value: 295 Titles: – TitleFull: American heart journal Type: main |
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