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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) trial: a protocol for a pragmatic randomised study of diverticulitis treatment in the USA.

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Title: Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) trial: a protocol for a pragmatic randomised study of diverticulitis treatment in the USA.
Authors: Hantouli MN; Surgery, University of Washington, Seattle, Washington, USA hantouli@uw.edu., Schmicker RH; Biostatistics, University of Washington, Seattle, Washington, USA., Tufte JE; Ambassador, PCORI, Washington, District of Columbia, USA., Ali FG; Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Bennett RD; Colon & Rectal Surgery, University of South Florida, Tampa, Florida, USA., Cohan JN; Surgery, University of Utah Health, Salt Lake City, Utah, USA., Comstock BA; Biostatistics, University of Washington, Seattle, Washington, USA., Curran T; Surgery, Medical University of South Carolina, Charleston, South Carolina, USA., Davidson GH; Surgery, University of Washington, Seattle, Washington, USA., Eisenstein S; Surgery, UC San Diego, La Jolla, California, USA., Fischkoff KN; Surgery, Columbia University Medical Center, New York City, New York, USA., Fleming FJ; Colorectal Surgery, University of Rochester Medical Center, Rochester, New York, USA., Gribovskaja-Rupp I; University of Iowa Health Care, Iowa City, Iowa, USA., Jafari MD; Surgery, Weill Cornell Medicine, New York City, New York, USA., Kessler LG; Health Services, University of Washington, Seattle, Washington, USA., Krane MK; Surgery, University of Washington, Seattle, Washington, USA., Lawrence SO; Surgery, University of Washington, Seattle, Washington, USA., McCormick JT; Colon & Rectal Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Millas SG; Surgery, The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, Houston, Texas, USA., Morris AM; Stanford University, Stanford, California, USA., Pullar KM; Surgery, University of Washington, Seattle, Washington, USA., Reinke CE; Carolinas Medical Center, Charlotte, North Carolina, USA., Saraidaridis JT; Surgery, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA., Simianu VV; Virginia Mason Medical Center, Seattle, Washington, USA., Watkins SP; Surgery, University of Washington, Seattle, Washington, USA., White NB; Surgery, University of Washington, Seattle, Washington, USA., Wick EC; School of Medicine, UCSF, San Francisco, California, USA., Wieghard N; Surgery, Virginia Commonwealth University, Richmond, Virginia, USA., Flum DR; Surgery, University of Washington, Seattle, Washington, USA., Read TE; Gastrointestinal Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Corporate Authors: COSMID Collaborative
Source: BMJ open [BMJ Open] 2026 Jan 08; Vol. 16 (1), pp. e098309. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) trial: a protocol for a pragmatic randomised study of diverticulitis treatment in the USA.
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  Data: <searchLink fieldCode="AU" term="%22Hantouli+MN%22">Hantouli MN</searchLink>; Surgery, University of Washington, Seattle, Washington, USA hantouli@uw.edu.<br /><searchLink fieldCode="AU" term="%22Schmicker+RH%22">Schmicker RH</searchLink>; Biostatistics, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Tufte+JE%22">Tufte JE</searchLink>; Ambassador, PCORI, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Ali+FG%22">Ali FG</searchLink>; Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+RD%22">Bennett RD</searchLink>; Colon & Rectal Surgery, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Cohan+JN%22">Cohan JN</searchLink>; Surgery, University of Utah Health, Salt Lake City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Comstock+BA%22">Comstock BA</searchLink>; Biostatistics, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Curran+T%22">Curran T</searchLink>; Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+GH%22">Davidson GH</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Eisenstein+S%22">Eisenstein S</searchLink>; Surgery, UC San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Fischkoff+KN%22">Fischkoff KN</searchLink>; Surgery, Columbia University Medical Center, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Fleming+FJ%22">Fleming FJ</searchLink>; Colorectal Surgery, University of Rochester Medical Center, Rochester, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gribovskaja-Rupp+I%22">Gribovskaja-Rupp I</searchLink>; University of Iowa Health Care, Iowa City, Iowa, USA.<br /><searchLink fieldCode="AU" term="%22Jafari+MD%22">Jafari MD</searchLink>; Surgery, Weill Cornell Medicine, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kessler+LG%22">Kessler LG</searchLink>; Health Services, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Krane+MK%22">Krane MK</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+SO%22">Lawrence SO</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22McCormick+JT%22">McCormick JT</searchLink>; Colon & Rectal Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Millas+SG%22">Millas SG</searchLink>; Surgery, The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Morris+AM%22">Morris AM</searchLink>; Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Pullar+KM%22">Pullar KM</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Reinke+CE%22">Reinke CE</searchLink>; Carolinas Medical Center, Charlotte, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Saraidaridis+JT%22">Saraidaridis JT</searchLink>; Surgery, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Simianu+VV%22">Simianu VV</searchLink>; Virginia Mason Medical Center, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Watkins+SP%22">Watkins SP</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22White+NB%22">White NB</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wick+EC%22">Wick EC</searchLink>; School of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Wieghard+N%22">Wieghard N</searchLink>; Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Flum+DR%22">Flum DR</searchLink>; Surgery, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Read+TE%22">Read TE</searchLink>; Gastrointestinal Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101552874 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2044-6055 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220446055%22">20446055 </searchLink><i>NLM ISO Abbreviation: </i>BMJ Open <i>Subsets: </i>MEDLINE
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