Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome.
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| Title: | Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome. |
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| Authors: | Jin Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Cao Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China., Ma W; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Li R; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Li Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Kang Y; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Huang J; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Epstein MP; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Guo X; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Lim J; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Rivera N; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Zhou Y; Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA., Wen Z; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Cell Biology, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA., Allen EG; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA., Jin P; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA. peng.jin@emory.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jan 08; Vol. 17 (1), pp. 1418. Date of Electronic Publication: 2026 Jan 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41507195 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jin+Y%22">Jin Y</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Ma+W%22">Ma W</searchLink>; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+MP%22">Epstein MP</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lim+J%22">Lim J</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+N%22">Rivera N</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+Z%22">Wen Z</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Cell Biology, School of Medicine, Emory University, Atlanta, GA, USA.; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Allen+EG%22">Allen EG</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Jin+P%22">Jin P</searchLink>; Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA. peng.jin@emory.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 08; Vol. 17 (1), pp. 1418. <i>Date of Electronic Publication: </i>2026 Jan 08. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41507195 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-68163-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1418 Titles: – TitleFull: Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jin Y – PersonEntity: Name: NameFull: Cao Y – PersonEntity: Name: NameFull: Ma W – PersonEntity: Name: NameFull: Li R – PersonEntity: Name: NameFull: Li Y – PersonEntity: Name: NameFull: Kang Y – PersonEntity: Name: NameFull: Huang J – PersonEntity: Name: NameFull: Epstein MP – PersonEntity: Name: NameFull: Guo X – PersonEntity: Name: NameFull: Lim J – PersonEntity: Name: NameFull: Rivera N – PersonEntity: Name: NameFull: Zhou Y – PersonEntity: Name: NameFull: Wen Z – PersonEntity: Name: NameFull: Allen EG – PersonEntity: Name: NameFull: Jin P IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 01 Text: 2026 Jan 08 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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