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Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity.

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Title: Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity.
Authors: Chen B; Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Sun G; Maize Research Institute, Sichuan Agricultural University, Chengdu, China., Kloeber JA; Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Medical Scientist Training Program, Mayo Clinic, Rochester, MN, USA., Xiao H; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Ouyang Y; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Zhao F; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Li Y; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Xu S; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Dragojevic S; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Wu Z; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Zhu S; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Han Y; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Yin P; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Tu X; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA., Qin H; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Zhou X; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Luo K; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Peterson KL; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Huang J; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Hitosugi T; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Dai H; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Deng M; State Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. dengmin@cicams.ac.cn., Mutter RW; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA. Mutter.Robert@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Mutter.Robert@mayo.edu., Lou Z; Department of Oncology, Mayo Clinic, Rochester, MN, USA. Lou.Zhenkun@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Lou.Zhenkun@mayo.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 Feb; Vol. 33 (2), pp. 293-303. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity.
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  Data: <searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sun+G%22">Sun G</searchLink>; Maize Research Institute, Sichuan Agricultural University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Kloeber+JA%22">Kloeber JA</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Medical Scientist Training Program, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+H%22">Xiao H</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ouyang+Y%22">Ouyang Y</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+F%22">Zhao F</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Dragojevic+S%22">Dragojevic S</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+S%22">Zhu S</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Yin+P%22">Yin P</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Tu+X%22">Tu X</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Qin+H%22">Qin H</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Luo+K%22">Luo K</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+KL%22">Peterson KL</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hitosugi+T%22">Hitosugi T</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dai+H%22">Dai H</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Deng+M%22">Deng M</searchLink>; State Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. dengmin@cicams.ac.cn.<br /><searchLink fieldCode="AU" term="%22Mutter+RW%22">Mutter RW</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA. Mutter.Robert@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Mutter.Robert@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Lou+Z%22">Lou Z</searchLink>; Department of Oncology, Mayo Clinic, Rochester, MN, USA. Lou.Zhenkun@mayo.edu.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Lou.Zhenkun@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%22101186374%22">Nature structural & molecular biology</searchLink> [Nat Struct Mol Biol] 2026 Feb; Vol. 33 (2), pp. 293-303. <i>Date of Electronic Publication: </i>2026 Jan 08.
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