Mapping the secondary response to traumatic brain injury using spatial transcriptomics shows acute 4-aminopyridine treatment mitigates axonal and molecular pathology.
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| Title: | Mapping the secondary response to traumatic brain injury using spatial transcriptomics shows acute 4-aminopyridine treatment mitigates axonal and molecular pathology. |
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| Authors: | Sullivan GM; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA., Radomski KL; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA., He S; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA., Wilkerson MD; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA., Dalgard CL; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA., Alba C; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA., Zi X; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA., Doughty ML; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA., Armstrong RC; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA. regina.armstrong@usuhs.edu.; Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, USA. regina.armstrong@usuhs.edu. |
| Source: | Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Jan 08; Vol. 14 (1), pp. 36. Date of Electronic Publication: 2026 Jan 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41508250 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Mapping the secondary response to traumatic brain injury using spatial transcriptomics shows acute 4-aminopyridine treatment mitigates axonal and molecular pathology. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sullivan+GM%22">Sullivan GM</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Radomski+KL%22">Radomski KL</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.<br /><searchLink fieldCode="AU" term="%22He+S%22">He S</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wilkerson+MD%22">Wilkerson MD</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dalgard+CL%22">Dalgard CL</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Alba+C%22">Alba C</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Center for Military Precision Health, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zi+X%22">Zi X</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.; Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Doughty+ML%22">Doughty ML</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA.<br /><searchLink fieldCode="AU" term="%22Armstrong+RC%22">Armstrong RC</searchLink>; Department of Anatomy, Physiology and Genetics in the School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, 4301 Jones Bridge Rd., Bethesda, MD, 20814, USA. regina.armstrong@usuhs.edu.; Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, USA. regina.armstrong@usuhs.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 Jan 08; Vol. 14 (1), pp. 36. <i>Date of Electronic Publication: </i>2026 Jan 08. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41508250 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s40478-025-02219-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 36 Titles: – TitleFull: Mapping the secondary response to traumatic brain injury using spatial transcriptomics shows acute 4-aminopyridine treatment mitigates axonal and molecular pathology. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sullivan GM – PersonEntity: Name: NameFull: Radomski KL – PersonEntity: Name: NameFull: He S – PersonEntity: Name: NameFull: Wilkerson MD – PersonEntity: Name: NameFull: Dalgard CL – PersonEntity: Name: NameFull: Alba C – PersonEntity: Name: NameFull: Zi X – PersonEntity: Name: NameFull: Doughty ML – PersonEntity: Name: NameFull: Armstrong RC IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 01 Text: 2026 Jan 08 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2051-5960 Numbering: – Type: volume Value: 14 – Type: issue Value: 1 Titles: – TitleFull: Acta neuropathologica communications Type: main |
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