Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology.
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| Title: | Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology. |
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| Authors: | Wu Y; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China., Sun X; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Reddy JS; The Department of Quantitative Health Sciences, Mayo Clinic, Florida, 4500 San Pablo Rd S. Jacksonville, Florida, FL 32224, USA., Advani PP; The Department of Hematology and Oncology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA., Boddicker NJ; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA., Cerhan JR; Division of Epidemiology, Mayo Clinic, Rochester, MN, USA., Villarraga HR; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Asirvatham SJ; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Wang RX; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China., Lee HC; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Norton N; The Department of Cancer Biology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA., Lu T; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 02. Date of Electronic Publication: 2026 Jan 02. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41509376 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+JS%22">Reddy JS</searchLink>; The Department of Quantitative Health Sciences, Mayo Clinic, Florida, 4500 San Pablo Rd S. Jacksonville, Florida, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Advani+PP%22">Advani PP</searchLink>; The Department of Hematology and Oncology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Boddicker+NJ%22">Boddicker NJ</searchLink>; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cerhan+JR%22">Cerhan JR</searchLink>; Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Villarraga+HR%22">Villarraga HR</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Asirvatham+SJ%22">Asirvatham SJ</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wang+RX%22">Wang RX</searchLink>; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lee+HC%22">Lee HC</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Norton+N%22">Norton N</searchLink>; The Department of Cancer Biology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jan 02. <i>Date of Electronic Publication: </i>2026 Jan 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41509376 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.64898/2026.01.01.697223 Languages: – Code: eng Text: English Titles: – TitleFull: Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wu Y – PersonEntity: Name: NameFull: Sun X – PersonEntity: Name: NameFull: Reddy JS – PersonEntity: Name: NameFull: Advani PP – PersonEntity: Name: NameFull: Boddicker NJ – PersonEntity: Name: NameFull: Cerhan JR – PersonEntity: Name: NameFull: Villarraga HR – PersonEntity: Name: NameFull: Asirvatham SJ – PersonEntity: Name: NameFull: Wang RX – PersonEntity: Name: NameFull: Lee HC – PersonEntity: Name: NameFull: Norton N – PersonEntity: Name: NameFull: Lu T IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 01 Text: 2026 Jan 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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