Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology.

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Title: Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology.
Authors: Wu Y; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China., Sun X; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Reddy JS; The Department of Quantitative Health Sciences, Mayo Clinic, Florida, 4500 San Pablo Rd S. Jacksonville, Florida, FL 32224, USA., Advani PP; The Department of Hematology and Oncology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA., Boddicker NJ; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA., Cerhan JR; Division of Epidemiology, Mayo Clinic, Rochester, MN, USA., Villarraga HR; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Asirvatham SJ; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Wang RX; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China., Lee HC; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA., Norton N; The Department of Cancer Biology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA., Lu T; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 02. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+JS%22">Reddy JS</searchLink>; The Department of Quantitative Health Sciences, Mayo Clinic, Florida, 4500 San Pablo Rd S. Jacksonville, Florida, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Advani+PP%22">Advani PP</searchLink>; The Department of Hematology and Oncology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Boddicker+NJ%22">Boddicker NJ</searchLink>; Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cerhan+JR%22">Cerhan JR</searchLink>; Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Villarraga+HR%22">Villarraga HR</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Asirvatham+SJ%22">Asirvatham SJ</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wang+RX%22">Wang RX</searchLink>; The Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214023, Jiangsu Province, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lee+HC%22">Lee HC</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Norton+N%22">Norton N</searchLink>; The Department of Cancer Biology, Mayo Clinic, Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; The Departments of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jan 02. <i>Date of Electronic Publication: </i>2026 Jan 02.
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        Value: 10.64898/2026.01.01.697223
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              Text: 2026 Jan 02
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