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THP-1-derived polarized macrophages differ by drug transporter transcriptomics, P-glycoprotein activity and rifampicin uptake kinetics.

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Title: THP-1-derived polarized macrophages differ by drug transporter transcriptomics, P-glycoprotein activity and rifampicin uptake kinetics.
Authors: Hamburg K; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology Medical Faculty Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Bay C; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology Medical Faculty Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Burhenne J; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology Medical Faculty Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Weiss J; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology Medical Faculty Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Stingl JC; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology Medical Faculty Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany., Theile D; Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology Medical Faculty Heidelberg, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. dirk.theile@med.uni-heidelberg.de.
Source: Archives of toxicology [Arch Toxicol] 2026 Apr; Vol. 100 (4), pp. 1377-1389. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-025-04270-2