Targeting the JAK2/STAT3 Axis and Remodeling the Tumour Microenvironment: The Dual Anti-Tumour Mechanism of Total Glucosides of Paeony in Gallbladder Cancer.

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Title: Targeting the JAK2/STAT3 Axis and Remodeling the Tumour Microenvironment: The Dual Anti-Tumour Mechanism of Total Glucosides of Paeony in Gallbladder Cancer.
Authors: Lin KN; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang Province, China; Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China., Yu XF; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Lin ZH; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Shan YK; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang Province, China; Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China., Ying ZG; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Feng H; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Zhang LZ; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Liu YY; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Shen HZ; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Hong YJ; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China., Li QL; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: qinglin200886@126.com., Jin RA; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang Province, China; Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China. Electronic address: jason198508@zju.edu.cn.
Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jan; Vol. 150, pp. 157756. Date of Electronic Publication: 2026 Jan 01.
Publication Type: Journal Article
Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting the JAK2/STAT3 Axis and Remodeling the Tumour Microenvironment: The Dual Anti-Tumour Mechanism of Total Glucosides of Paeony in Gallbladder Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lin+KN%22">Lin KN</searchLink>; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang Province, China; Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Yu+XF%22">Yu XF</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Lin+ZH%22">Lin ZH</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Shan+YK%22">Shan YK</searchLink>; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang Province, China; Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Ying+ZG%22">Ying ZG</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Feng+H%22">Feng H</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+LZ%22">Zhang LZ</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Liu+YY%22">Liu YY</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Shen+HZ%22">Shen HZ</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Hong+YJ%22">Hong YJ</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Li+QL%22">Li QL</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, China. Electronic address: qinglin200886@126.com.<br /><searchLink fieldCode="AU" term="%22Jin+RA%22">Jin RA</searchLink>; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, Zhejiang Province, China; Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China. Electronic address: jason198508@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229438794%22">Phytomedicine : international journal of phytotherapy and phytopharmacology</searchLink> [Phytomedicine] 2026 Jan; Vol. 150, pp. 157756. <i>Date of Electronic Publication: </i>2026 Jan 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Urban+%26+Fischer+Verlag%22">Urban & Fischer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9438794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-095X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209447113%22">09447113 </searchLink><i>NLM ISO Abbreviation: </i>Phytomedicine <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.phymed.2025.157756
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        Text: English
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      – TitleFull: Targeting the JAK2/STAT3 Axis and Remodeling the Tumour Microenvironment: The Dual Anti-Tumour Mechanism of Total Glucosides of Paeony in Gallbladder Cancer.
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              Text: 2026 Jan
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