Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.

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Bibliographic Details
Title: Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Authors: Guo L; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: lin.guo@jefferson.edu., Mann JR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Mauna JC; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Copley KE; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang H; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rubien JD; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bergmann CA; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Carey JL; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA., Merjane J; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ngo M; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Xu J; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Odeh HM; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lin J; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lee BL; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ganser L; Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA., Robinson E; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA., Kim KM; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA., Murthy AC; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA., Paul T; Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA., Portz B; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gleixner AM; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Diaz Z; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Smirnov A; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Padilla G; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lavorando E; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Espy C; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shang Y; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA., Huang EJ; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA., Chesi A; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fawzi NL; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA., Myong S; Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA., Donnelly CJ; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Live Like Lou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Protein Conformational Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Pittsburgh Institute for Neurodegeneration, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: cjdon25@pitt.edu., Shorter J; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jshorter@pennmedicine.upenn.edu.
Source: Molecular cell [Mol Cell] 2026 Jan 08; Vol. 86 (1), pp. 114-134.e10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4164
DOI:10.1016/j.molcel.2025.12.009