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Bioactive components of Xinyang and Xinyin tablets for treating chronic heart failure: Pharmacokinetics, network pharmacology and experimental validation.

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Title: Bioactive components of Xinyang and Xinyin tablets for treating chronic heart failure: Pharmacokinetics, network pharmacology and experimental validation.
Authors: Lan YL; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China., Chen SM; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Vaccines for Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361105, Fujian Province, China., Dai BX; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Vaccines for Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361105, Fujian Province, China., Wu CS; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Vaccines for Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361105, Fujian Province, China., Wei Y; Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen 361105, Fujian Province, China., Yang L; College of Pharmacy, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China., Yan JL; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China., Guo YQ; General Practice Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China., Wang DW; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China., Li QG; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China., Yang ZQ; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China., Xian SX; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China. Electronic address: zhongyfy@126.com., Yuan TH; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; General Practice Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China. Electronic address: laura.yth@hotmail.com.
Source: Journal of integrative medicine [J Integr Med] 2026 Mar; Vol. 24 (2), pp. 265-278. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101603118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-4964 (Print) NLM ISO Abbreviation: J Integr Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lan+YL%22">Lan YL</searchLink>; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Chen+SM%22">Chen SM</searchLink>; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Vaccines for Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361105, Fujian Province, China.<br /><searchLink fieldCode="AU" term="%22Dai+BX%22">Dai BX</searchLink>; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Vaccines for Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361105, Fujian Province, China.<br /><searchLink fieldCode="AU" term="%22Wu+CS%22">Wu CS</searchLink>; Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Vaccines for Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361105, Fujian Province, China.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen 361105, Fujian Province, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; College of Pharmacy, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China.<br /><searchLink fieldCode="AU" term="%22Yan+JL%22">Yan JL</searchLink>; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Guo+YQ%22">Guo YQ</searchLink>; General Practice Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+DW%22">Wang DW</searchLink>; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Li+QG%22">Li QG</searchLink>; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Yang+ZQ%22">Yang ZQ</searchLink>; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Xian+SX%22">Xian SX</searchLink>; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China. Electronic address: zhongyfy@126.com.<br /><searchLink fieldCode="AU" term="%22Yuan+TH%22">Yuan TH</searchLink>; International Medical Center, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; General Practice Department, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China. Electronic address: laura.yth@hotmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101603118%22">Journal of integrative medicine</searchLink> [J Integr Med] 2026 Mar; Vol. 24 (2), pp. 265-278. <i>Date of Electronic Publication: </i>2025 Dec 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101603118 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2095-4964 (Print) <i>NLM ISO Abbreviation: </i>J Integr Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar
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