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Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer's disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort.

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Title: Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer's disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort.
Authors: Fandos N; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: nfandos@araclon.com., Pascual-Lucas M; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: mpascual@araclon.com., Sarasa L; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: letisarasa@araclon.com., Terencio J; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain; Scientific Innovation Office, Grifols. Parque Empresarial Can Sant Joan, Avinguda de la Generalitat, 152-158, 08174 Sant Cugat del Vallès, Barcelona, Spain. Electronic address: jose.terencio@grifols.com., Sáez ME; CAEBi Bioinformática S.L. Pasaje Antonio Villegas 16, 41704 Dos Hermanas, Sevilla, Spain. Electronic address: mesaez@caebi.es., Tartari JP; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain. Electronic address: jptartari@fundacioace.org., Sanabria Á; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: asanabria@fundacioace.org., Sotolongo-Grau O; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain. Electronic address: osotolongo@fundacioace.org., Cano A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: acano@fundacioace.org., Tárraga L; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: ltarraga@fundacioace.org., Gurruchaga MJ; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain. Electronic address: miren@fundacioace.org., Ruíz A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center. 8300 Floyd Curl Drive, San Antonio, TX 78229, USA; Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine. University of Texas Health Science Center. 7703 Floyd Curl Drive, San Antonio, TX 78229 MC 7758, USA. Electronic address: aruiz@fundacioace.org., Montalban X; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain; Department of Neurology and Multiple Sclerosis Center of Catalonia (Cemcat), Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona (UAB). Pg. de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain. Electronic address: xmontalban@fundacioace.org., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: mboada@fundacioace.org., Alegret M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: malegret@fundacioace.org., Marquié M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: mmarquie@fundacioace.org., Allué JA; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: jallue@araclon.com.
Corporate Authors: FACEHBI study group, AMYPAD consortium
Source: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2026 Mar; Vol. 13 (3), pp. 100465. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: United States NLM ID: 101638820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2426-0266 (Electronic) Linking ISSN: 22745807 NLM ISO Abbreviation: J Prev Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer's disease in individuals with subjective cognitive decline: 5-year follow-up of the FACEHBI cohort.
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  Data: <searchLink fieldCode="AU" term="%22Fandos+N%22">Fandos N</searchLink>; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: nfandos@araclon.com.<br /><searchLink fieldCode="AU" term="%22Pascual-Lucas+M%22">Pascual-Lucas M</searchLink>; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: mpascual@araclon.com.<br /><searchLink fieldCode="AU" term="%22Sarasa+L%22">Sarasa L</searchLink>; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: letisarasa@araclon.com.<br /><searchLink fieldCode="AU" term="%22Terencio+J%22">Terencio J</searchLink>; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain; Scientific Innovation Office, Grifols. Parque Empresarial Can Sant Joan, Avinguda de la Generalitat, 152-158, 08174 Sant Cugat del Vallès, Barcelona, Spain. Electronic address: jose.terencio@grifols.com.<br /><searchLink fieldCode="AU" term="%22Sáez+ME%22">Sáez ME</searchLink>; CAEBi Bioinformática S.L. Pasaje Antonio Villegas 16, 41704 Dos Hermanas, Sevilla, Spain. Electronic address: mesaez@caebi.es.<br /><searchLink fieldCode="AU" term="%22Tartari+JP%22">Tartari JP</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain. Electronic address: jptartari@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Sanabria+Á%22">Sanabria Á</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: asanabria@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Sotolongo-Grau+O%22">Sotolongo-Grau O</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain. Electronic address: osotolongo@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Cano+A%22">Cano A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: acano@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Tárraga+L%22">Tárraga L</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: ltarraga@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Gurruchaga+MJ%22">Gurruchaga MJ</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain. Electronic address: miren@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Ruíz+A%22">Ruíz A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center. 8300 Floyd Curl Drive, San Antonio, TX 78229, USA; Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine. University of Texas Health Science Center. 7703 Floyd Curl Drive, San Antonio, TX 78229 MC 7758, USA. Electronic address: aruiz@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Montalban+X%22">Montalban X</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain; Department of Neurology and Multiple Sclerosis Center of Catalonia (Cemcat), Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona (UAB). Pg. de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain. Electronic address: xmontalban@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: mboada@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Alegret+M%22">Alegret M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: malegret@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Marquié+M%22">Marquié M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya. C/ Gran Via de Carles III, 85 bis, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III. C/ Melchor Fernández Almagro, 3, Fuencarral-El Pardo, 28029 Madrid, Spain. Electronic address: mmarquie@fundacioace.org.<br /><searchLink fieldCode="AU" term="%22Allué+JA%22">Allué JA</searchLink>; Araclon Biotech-Grifols. Vía Hispanidad 21, 50009 Zaragoza, Spain. Electronic address: jallue@araclon.com.
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  Data: <searchLink fieldCode="JN" term="%22101638820%22">The journal of prevention of Alzheimer's disease</searchLink> [J Prev Alzheimers Dis] 2026 Mar; Vol. 13 (3), pp. 100465. <i>Date of Electronic Publication: </i>2026 Jan 08.
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