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Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system.

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Title: Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system.
Authors: Nunes M; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa. mnunes@sun.ac.za., Kell L; Botnar Institute for Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK., Slaghekke A; Department of Human Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Wüst RC; Department of Human Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Fielding BC; Department of Microbiology, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa., Kell DB; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.; The Novo Nordisk Foundation Centre for Biosustainability, Building 220, Chemitorvet 200, Technical University of Denmark, Kongens Lyngby, Denmark., Pretorius E; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa. resiap@sun.ac.za.; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK. resiap@sun.ac.za.
Source: Cell death & disease [Cell Death Dis] 2026 Jan 09; Vol. 17 (1), pp. 16. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system.
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  Data: <searchLink fieldCode="AU" term="%22Nunes+M%22">Nunes M</searchLink>; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa. mnunes@sun.ac.za.<br /><searchLink fieldCode="AU" term="%22Kell+L%22">Kell L</searchLink>; Botnar Institute for Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Slaghekke+A%22">Slaghekke A</searchLink>; Department of Human Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Wüst+RC%22">Wüst RC</searchLink>; Department of Human Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Fielding+BC%22">Fielding BC</searchLink>; Department of Microbiology, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Kell+DB%22">Kell DB</searchLink>; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.; The Novo Nordisk Foundation Centre for Biosustainability, Building 220, Chemitorvet 200, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Pretorius+E%22">Pretorius E</searchLink>; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa. resiap@sun.ac.za.; Department of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK. resiap@sun.ac.za.
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              Text: 2026 Jan 09
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