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Distinct genomic, microenvironmental, and nephron signatures in VHL kidney cysts and tumors.

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Title: Distinct genomic, microenvironmental, and nephron signatures in VHL kidney cysts and tumors.
Authors: Rowe I; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy. rowe.isaline@hsr.it., Corea F; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Pipitone GB; Laboratory of Clinical Molecular Genetics, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scotti GM; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Lucianò R; Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sant'Angelo M; Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Tenace NP; Università Vita-Salute San Raffaele, Milan, Italy.; Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Franco I; Università Vita-Salute San Raffaele, Milan, Italy.; Somatic Mutation Mechanisms Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy., Ferrara AM; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy., Doglioni C; Università Vita-Salute San Raffaele, Milan, Italy.; Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ponzoni M; Università Vita-Salute San Raffaele, Milan, Italy.; Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy., De Cobelli F; Università Vita-Salute San Raffaele, Milan, Italy.; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Montorsi F; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Capitanio U; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Carrera P; Laboratory of Clinical Molecular Genetics, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Genomics for Diagnosis of Human Disease Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Larcher A; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy., Salonia A; Comprehensive Cancer Center, Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy. salonia.andrea@hsr.it.; Università Vita-Salute San Raffaele, Milan, Italy. salonia.andrea@hsr.it.
Corporate Authors: VHL OSR Program
Source: Scientific reports [Sci Rep] 2026 Jan 09; Vol. 16 (1), pp. 4394. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-34381-w