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Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.

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Title: Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.
Authors: Konsue A; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand., Gleeson D; Department of Chemistry, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand., Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand., Jones DJL; Department of Cancer Studies, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom., Hannanta-Anan P; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand., Britton RG; Department of Cancer Studies, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom., Gleeson MP; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand. Electronic address: paul.gl@kmitl.ac.th.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Mar; Vol. 134, pp. 118544. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2025.118544