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Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.

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Title: Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.
Authors: Konsue A; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand., Gleeson D; Department of Chemistry, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand., Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand., Jones DJL; Department of Cancer Studies, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom., Hannanta-Anan P; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand., Britton RG; Department of Cancer Studies, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom., Gleeson MP; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand. Electronic address: paul.gl@kmitl.ac.th.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 Mar; Vol. 134, pp. 118544. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Computationally guided design of N<superscript>4</superscript>-(2-methyl-2H-indazol-6-yl)-N<superscript>2</superscript>-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.
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  Data: <searchLink fieldCode="AU" term="%22Konsue+A%22">Konsue A</searchLink>; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Gleeson+D%22">Gleeson D</searchLink>; Department of Chemistry, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Choowongkomon+K%22">Choowongkomon K</searchLink>; Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.<br /><searchLink fieldCode="AU" term="%22Jones+DJL%22">Jones DJL</searchLink>; Department of Cancer Studies, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hannanta-Anan+P%22">Hannanta-Anan P</searchLink>; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Britton+RG%22">Britton RG</searchLink>; Department of Cancer Studies, Leicester Cancer Research Centre, University of Leicester, Leicester LE1 7RH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gleeson+MP%22">Gleeson MP</searchLink>; Department of Biomedical Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand. Electronic address: paul.gl@kmitl.ac.th.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2026 Mar; Vol. 134, pp. 118544. <i>Date of Electronic Publication: </i>2026 Jan 02.
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        Value: 10.1016/j.bmc.2025.118544
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      – Code: eng
        Text: English
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      – TitleFull: Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.
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              Text: 2026 Mar
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              Y: 2026
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