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Efficacy and safety of brensocatib in Japanese patients with non-cystic fibrosis bronchiectasis: Analysis of the ASPEN trial.

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Title: Efficacy and safety of brensocatib in Japanese patients with non-cystic fibrosis bronchiectasis: Analysis of the ASPEN trial.
Authors: Morimoto K; Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo, 204-8522, Japan. Electronic address: morimotok@fukujuji.org., Chalmers JD; Division of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Ave., Dundee, Scotland, DD1 4HN, UK., Burgel PR; Hôpital Cochin and Cystic Fibrosis National Reference Center, Service de Pneumologie, AP-HP and Université Paris-Cité, Inserm U1016-Institut Cochin, 27 rue de faubourg Saint-Jacques, 75014, Paris, France., Daley CL; National Jewish Health, 1400 Jackson St, Denver, CO, 80206, USA., De Soyza A; Population and Health Sciences Institute, NIHR Biomedical Research Centre for Aging Newcastle University and Department of Respiratory Medicine, Newcastle upon Tyne NHS Foundation Trust, Room L2060, Framlington Place, Newcastle upon Tyne, NE2 4AX, UK., Mauger D; Pennsylvania State University, A210 Public Health Sciences, Hershey, PA, 17033, USA., Metersky ML; University of Connecticut School of Medicine, 263 Farmington Ave., Farmington, CT, 06030, USA., Zhang X; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA., Li S; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA., Goto Y; Insmed GK, Tokyu Capitol Tower 13th Floor, 2-10-3, Nagata-cho, Chiyoda-ku, Tokyo, 100-0014, Japan., Teper A; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA., Fernandez C; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA., Hasegawa N; Center for Clinical Infectious Diseases, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Source: Respiratory investigation [Respir Investig] 2026 Mar; Vol. 64 (2), pp. 101357. Date of Electronic Publication: 2026 Jan 09.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101581124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-5353 (Electronic) Linking ISSN: 22125345 NLM ISO Abbreviation: Respir Investig Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Morimoto+K%22">Morimoto K</searchLink>; Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo, 204-8522, Japan. Electronic address: morimotok@fukujuji.org.<br /><searchLink fieldCode="AU" term="%22Chalmers+JD%22">Chalmers JD</searchLink>; Division of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Ave., Dundee, Scotland, DD1 4HN, UK.<br /><searchLink fieldCode="AU" term="%22Burgel+PR%22">Burgel PR</searchLink>; Hôpital Cochin and Cystic Fibrosis National Reference Center, Service de Pneumologie, AP-HP and Université Paris-Cité, Inserm U1016-Institut Cochin, 27 rue de faubourg Saint-Jacques, 75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Daley+CL%22">Daley CL</searchLink>; National Jewish Health, 1400 Jackson St, Denver, CO, 80206, USA.<br /><searchLink fieldCode="AU" term="%22De+Soyza+A%22">De Soyza A</searchLink>; Population and Health Sciences Institute, NIHR Biomedical Research Centre for Aging Newcastle University and Department of Respiratory Medicine, Newcastle upon Tyne NHS Foundation Trust, Room L2060, Framlington Place, Newcastle upon Tyne, NE2 4AX, UK.<br /><searchLink fieldCode="AU" term="%22Mauger+D%22">Mauger D</searchLink>; Pennsylvania State University, A210 Public Health Sciences, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Metersky+ML%22">Metersky ML</searchLink>; University of Connecticut School of Medicine, 263 Farmington Ave., Farmington, CT, 06030, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA.<br /><searchLink fieldCode="AU" term="%22Goto+Y%22">Goto Y</searchLink>; Insmed GK, Tokyu Capitol Tower 13th Floor, 2-10-3, Nagata-cho, Chiyoda-ku, Tokyo, 100-0014, Japan.<br /><searchLink fieldCode="AU" term="%22Teper+A%22">Teper A</searchLink>; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA.<br /><searchLink fieldCode="AU" term="%22Fernandez+C%22">Fernandez C</searchLink>; Insmed Incorporated, 700 US Highway 202/206, Bridgewater, NJ, 08807, USA.<br /><searchLink fieldCode="AU" term="%22Hasegawa+N%22">Hasegawa N</searchLink>; Center for Clinical Infectious Diseases, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101581124%22">Respiratory investigation</searchLink> [Respir Investig] 2026 Mar; Vol. 64 (2), pp. 101357. <i>Date of Electronic Publication: </i>2026 Jan 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101581124 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2212-5353 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222125345%22">22125345 </searchLink><i>NLM ISO Abbreviation: </i>Respir Investig <i>Subsets: </i>MEDLINE
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