A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial.
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| Title: | A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial. |
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| Authors: | Fonteneau C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Tamayo Z; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Price A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Pan L; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Afriyie-Agyemang Y; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Agrawal S; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Butler A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Cail C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Calkins M; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Chakilam AR; AbbVie Inc., North Chicago IL, USA., Forselius-Bielen K; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Fram G; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Frazier A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Gil R; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Govil P; New York State Psychiatric Institute, New York NY, USA., Gray DL; Vigil Neuroscience, Watertown MA, USA., Grinband J; New York State Psychiatric Institute, New York NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA; Department of Radiology, Columbia University Irving Medical Center, New York NY, USA., Gur RC; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Haubold NK; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Heffernan Z; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Heneks M; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Kegeles L; New York State Psychiatric Institute, New York NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA., Kohler C; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Lin C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Lu J; Investigational Drug Service, Yale New Haven Hospital, New Haven CT, USA., Mayer M; New York State Psychiatric Institute, New York NY, USA., Pham P; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Perlman G; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Rahmati M; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Ranganathan M; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; VA Connecticut Healthcare System, West Haven CT, USA., Santamauro NP; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Schutte CW; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Selloni A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Van Snellenberg J; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Surti T; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; VA Connecticut Healthcare System, West Haven CT, USA., Wolf DH; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Zharyy C; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Abi-Dargham A; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA., Gur RE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA., Lieberman JA; Columbia University, College of Physicians and Surgeons, New York NY, USA., Kantrowitz JT; New York State Psychiatric Institute, New York NY, USA; Columbia University, College of Physicians and Surgeons, New York NY, USA; Nathan Kline Institute, Orangeburg NY, USA., Anticevic A; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA., Cho YT; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven CT, USA; Child Study Center, Yale University School of Medicine, New Haven CT, USA. Electronic address: youngsun.cho@yale.edu., Krystal JH; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA. |
| Corporate Authors: | TRANSCENDS Group; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA. |
| Source: | Journal of psychiatric research [J Psychiatr Res] 2026 Mar; Vol. 194, pp. 196-210. Date of Electronic Publication: 2025 Dec 16. |
| Publication Type: | Clinical Trial Protocol; Journal Article |
| Journal Info: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41519104 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Fonteneau+C%22">Fonteneau C</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Tamayo+Z%22">Tamayo Z</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Price+A%22">Price A</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Pan+L%22">Pan L</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Afriyie-Agyemang+Y%22">Afriyie-Agyemang Y</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Agrawal+S%22">Agrawal S</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Butler+A%22">Butler A</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Cail+C%22">Cail C</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Calkins+M%22">Calkins M</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.<br /><searchLink fieldCode="AU" term="%22Chakilam+AR%22">Chakilam AR</searchLink>; AbbVie Inc., North Chicago IL, USA.<br /><searchLink fieldCode="AU" term="%22Forselius-Bielen+K%22">Forselius-Bielen K</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Fram+G%22">Fram G</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Frazier+A%22">Frazier A</searchLink>; 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Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA.<br /><searchLink fieldCode="AU" term="%22Heffernan+Z%22">Heffernan Z</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.<br /><searchLink fieldCode="AU" term="%22Heneks+M%22">Heneks M</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Kegeles+L%22">Kegeles L</searchLink>; New York State Psychiatric Institute, New York NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA.<br /><searchLink fieldCode="AU" term="%22Kohler+C%22">Kohler C</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+C%22">Lin C</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Investigational Drug Service, Yale New Haven Hospital, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Mayer+M%22">Mayer M</searchLink>; New York State Psychiatric Institute, New York NY, USA.<br /><searchLink fieldCode="AU" term="%22Pham+P%22">Pham P</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Perlman+G%22">Perlman G</searchLink>; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA.<br /><searchLink fieldCode="AU" term="%22Rahmati+M%22">Rahmati M</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Ranganathan+M%22">Ranganathan M</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; VA Connecticut Healthcare System, West Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Santamauro+NP%22">Santamauro NP</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Schutte+CW%22">Schutte CW</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Selloni+A%22">Selloni A</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Van+Snellenberg+J%22">Van Snellenberg J</searchLink>; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA.<br /><searchLink fieldCode="AU" term="%22Surti+T%22">Surti T</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; VA Connecticut Healthcare System, West Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Wolf+DH%22">Wolf DH</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.<br /><searchLink fieldCode="AU" term="%22Zharyy+C%22">Zharyy C</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Abi-Dargham+A%22">Abi-Dargham A</searchLink>; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA.<br /><searchLink fieldCode="AU" term="%22Gur+RE%22">Gur RE</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA.<br /><searchLink fieldCode="AU" term="%22Lieberman+JA%22">Lieberman JA</searchLink>; Columbia University, College of Physicians and Surgeons, New York NY, USA.<br /><searchLink fieldCode="AU" term="%22Kantrowitz+JT%22">Kantrowitz JT</searchLink>; New York State Psychiatric Institute, New York NY, USA; Columbia University, College of Physicians and Surgeons, New York NY, USA; Nathan Kline Institute, Orangeburg NY, USA.<br /><searchLink fieldCode="AU" term="%22Anticevic+A%22">Anticevic A</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA.<br /><searchLink fieldCode="AU" term="%22Cho+YT%22">Cho YT</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven CT, USA; Child Study Center, Yale University School of Medicine, New Haven CT, USA. Electronic address: youngsun.cho@yale.edu.<br /><searchLink fieldCode="AU" term="%22Krystal+JH%22">Krystal JH</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22TRANSCENDS+Group%22">TRANSCENDS Group</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia PA, USA; Department of Psychiatry, Stony Brook University Renaissance School of Medicine, Stony Brook NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York NY, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220376331%22">Journal of psychiatric research</searchLink> [J Psychiatr Res] 2026 Mar; Vol. 194, pp. 196-210. <i>Date of Electronic Publication: </i>2025 Dec 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial Protocol; Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0376331 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1379 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223956%22">00223956 </searchLink><i>NLM ISO Abbreviation: </i>J Psychiatr Res <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jpsychires.2025.12.020 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 196 Titles: – TitleFull: A translational neuroscience & computational evaluation of a D1R partial agonist for schizophrenia (TRANSCENDS): Rationale and study design of a brain-based clinical trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fonteneau C – PersonEntity: Name: NameFull: Tamayo Z – PersonEntity: Name: NameFull: Price A – PersonEntity: Name: NameFull: Pan L – PersonEntity: Name: NameFull: Afriyie-Agyemang Y – PersonEntity: Name: NameFull: Agrawal S – PersonEntity: Name: NameFull: Butler A – PersonEntity: Name: NameFull: Cail C – PersonEntity: Name: NameFull: Calkins M – PersonEntity: Name: NameFull: Chakilam AR – PersonEntity: Name: NameFull: Forselius-Bielen K – PersonEntity: Name: NameFull: Fram G – PersonEntity: Name: NameFull: Frazier A – PersonEntity: Name: NameFull: Gil R – PersonEntity: Name: NameFull: Govil P – PersonEntity: Name: NameFull: Gray DL – PersonEntity: Name: NameFull: Grinband J – PersonEntity: Name: NameFull: Gur RC – PersonEntity: Name: NameFull: Haubold NK – PersonEntity: Name: NameFull: Heffernan Z – PersonEntity: Name: NameFull: Heneks M – PersonEntity: Name: NameFull: Kegeles L – PersonEntity: Name: NameFull: Kohler C – PersonEntity: Name: NameFull: Lin C – PersonEntity: Name: NameFull: Lu J – PersonEntity: Name: NameFull: Mayer M – PersonEntity: Name: NameFull: Pham P – PersonEntity: Name: NameFull: Perlman G – PersonEntity: Name: NameFull: Rahmati M – PersonEntity: Name: NameFull: Ranganathan M – PersonEntity: Name: NameFull: Santamauro NP – PersonEntity: Name: NameFull: Schutte CW – PersonEntity: Name: NameFull: Selloni A – PersonEntity: Name: NameFull: Van Snellenberg J – PersonEntity: Name: NameFull: Surti T – PersonEntity: Name: NameFull: Wolf DH – PersonEntity: Name: NameFull: Zharyy C – PersonEntity: Name: NameFull: Abi-Dargham A – PersonEntity: Name: NameFull: Gur RE – PersonEntity: Name: NameFull: Lieberman JA – PersonEntity: Name: NameFull: Kantrowitz JT – PersonEntity: Name: NameFull: Anticevic A – PersonEntity: Name: NameFull: Cho YT – PersonEntity: Name: NameFull: Krystal JH IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1879-1379 Numbering: – Type: volume Value: 194 Titles: – TitleFull: Journal of psychiatric research Type: main |
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