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The computationally designed TRI2-2 miniprotein inhibitor protects against multiple SARS-CoV-2 Omicron variants.

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Title: The computationally designed TRI2-2 miniprotein inhibitor protects against multiple SARS-CoV-2 Omicron variants.
Authors: Lee J; Department of Biochemistry, University of Washington, Seattle, WA, USA., Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Asarnow D; Department of Biochemistry, University of Washington, Seattle, WA, USA., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA, USA., Sanapala S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Carter L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dveesler@uw.edu.
Source: Communications biology [Commun Biol] 2026 Jan 10; Vol. 9 (1), pp. 224. Date of Electronic Publication: 2026 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Case+JB%22">Case JB</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Park+YJ%22">Park YJ</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ravichandran+R%22">Ravichandran R</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Asarnow+D%22">Asarnow D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Tortorici+MA%22">Tortorici MA</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JT%22">Brown JT</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sanapala+S%22">Sanapala S</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Carter+L%22">Carter L</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Diamond+MS%22">Diamond MS</searchLink>; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. mdiamond@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Veesler+D%22">Veesler D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dveesler@uw.edu.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2026 Jan 10; Vol. 9 (1), pp. 224. <i>Date of Electronic Publication: </i>2026 Jan 10.
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