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The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.

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Title: The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.
Authors: Dumontet T; Training Program in Organogenesis, Center for Cell Plasticity and Organ Design, University of Michigan, Ann Arbor, MI, USA. tdumonte@med.umich.edu.; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA. tdumonte@med.umich.edu., Basham KJ; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Foster MC; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Silverman E; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Heard KA; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Johnson D; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Lee C; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Plaska SW; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Breault DT; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA., Penton D; Electrophysiology Facility, University of Zurich, Zurich, Switzerland., Beuschlein F; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland.; Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität, Munich, Germany.; The LOOP Zurich - Medical Research Center, Zurich, Switzerland., Turcu AF; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., LaPensee CR; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Marcondes Lerario A; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA., Hammer GD; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.; Endocrine Oncology Program, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Source: Nature communications [Nat Commun] 2026 Jan 11; Vol. 17 (1), pp. 1535. Date of Electronic Publication: 2026 Jan 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.
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  Data: <searchLink fieldCode="AU" term="%22Dumontet+T%22">Dumontet T</searchLink>; Training Program in Organogenesis, Center for Cell Plasticity and Organ Design, University of Michigan, Ann Arbor, MI, USA. tdumonte@med.umich.edu.; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA. tdumonte@med.umich.edu.<br /><searchLink fieldCode="AU" term="%22Basham+KJ%22">Basham KJ</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Foster+MC%22">Foster MC</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Silverman+E%22">Silverman E</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Heard+KA%22">Heard KA</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+D%22">Johnson D</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lee+C%22">Lee C</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Plaska+SW%22">Plaska SW</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Breault+DT%22">Breault DT</searchLink>; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Penton+D%22">Penton D</searchLink>; Electrophysiology Facility, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beuschlein+F%22">Beuschlein F</searchLink>; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital of Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland.; Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität, Munich, Germany.; The LOOP Zurich - Medical Research Center, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Turcu+AF%22">Turcu AF</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22LaPensee+CR%22">LaPensee CR</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Marcondes+Lerario+A%22">Marcondes Lerario A</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hammer+GD%22">Hammer GD</searchLink>; Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.; Endocrine Oncology Program, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
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