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Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma.

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Title: Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma.
Authors: Feng HM; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.; Cuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Zhao Y; Department of Radiotherapy, Gansu Provincial People's Hospital, Lanzhou, China., Zhai KR; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China., Li B; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China leebin@lzu.edu.cn.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China., Song TN; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Meng YQ; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China., Huang HR; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.; Department of Pulmonary and Critical Care Medicine, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China., Li Z; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Cui BQ; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China., Yang N; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China., Su ZP; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jan 12; Vol. 14 (1). Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Feng+HM%22">Feng HM</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.; Cuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Radiotherapy, Gansu Provincial People's Hospital, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhai+KR%22">Zhai KR</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China leebin@lzu.edu.cn.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Song+TN%22">Song TN</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Meng+YQ%22">Meng YQ</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Huang+HR%22">Huang HR</searchLink>; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.; Department of Pulmonary and Critical Care Medicine, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Cui+BQ%22">Cui BQ</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+N%22">Yang N</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Su+ZP%22">Su ZP</searchLink>; Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Jan 12; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Jan 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1136/jitc-2025-013170
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      – Code: eng
        Text: English
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      – TitleFull: Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma.
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            – D: 12
              M: 01
              Text: 2026 Jan 12
              Type: published
              Y: 2026
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              Value: 2051-1426
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              Value: 14
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