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Small molecule splicing modulators that disrupt O-GlcNAc homeostasis.

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Title: Small molecule splicing modulators that disrupt O-GlcNAc homeostasis.
Authors: Cheng SS; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Mody AC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Vetere A; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Govindan A; Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, USA., Lee Y; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Khost DE; Informatics Group, Harvard University, Cambridge, MA, USA., Narayan R; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Sackton TB; Informatics Group, Harvard University, Cambridge, MA, USA., Conrad NK; Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, USA., Wagner BK; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Woo CM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.
Source: Nature communications [Nat Commun] 2026 Jan 12; Vol. 17 (1), pp. 1548. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small molecule splicing modulators that disrupt O-GlcNAc homeostasis.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+SS%22">Cheng SS</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mody+AC%22">Mody AC</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vetere+A%22">Vetere A</searchLink>; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Govindan+A%22">Govindan A</searchLink>; Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Khost+DE%22">Khost DE</searchLink>; Informatics Group, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Narayan+R%22">Narayan R</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sackton+TB%22">Sackton TB</searchLink>; Informatics Group, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Conrad+NK%22">Conrad NK</searchLink>; Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+BK%22">Wagner BK</searchLink>; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Woo+CM%22">Woo CM</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.; Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.
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        Value: 10.1038/s41467-025-68271-6
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              Text: 2026 Jan 12
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