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Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.

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Title: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.
Authors: Mace K; Pharmacology Graduate Group, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zimmerman A; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA., Chesi A; Center for Spatial and Functional Genomics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Doldur-Balli F; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kim H; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Almeraya Del Valle E; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rosa JB; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pack AI; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grant SFA; Center for Spatial and Functional Genomics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, USA.; Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Kayser MS; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kayser@pennmedicine.upenn.edu.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kayser@pennmedicine.upenn.edu.; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kayser@pennmedicine.upenn.edu.
Source: Nature communications [Nat Commun] 2026 Jan 12; Vol. 17 (1), pp. 1628. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.
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  Data: <searchLink fieldCode="AU" term="%22Mace+K%22">Mace K</searchLink>; Pharmacology Graduate Group, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zimmerman+A%22">Zimmerman A</searchLink>; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chesi+A%22">Chesi A</searchLink>; Center for Spatial and Functional Genomics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Doldur-Balli+F%22">Doldur-Balli F</searchLink>; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Almeraya+Del+Valle+E%22">Almeraya Del Valle E</searchLink>; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rosa+JB%22">Rosa JB</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pack+AI%22">Pack AI</searchLink>; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Grant+SFA%22">Grant SFA</searchLink>; Center for Spatial and Functional Genomics, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, USA.; Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kayser+MS%22">Kayser MS</searchLink>; Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kayser@pennmedicine.upenn.edu.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kayser@pennmedicine.upenn.edu.; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kayser@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 12; Vol. 17 (1), pp. 1628. <i>Date of Electronic Publication: </i>2026 Jan 12.
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