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Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq.

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Title: Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq.
Authors: Xu W; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangdong, China. xuwei2023@gzhmu.edu.cn.; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China. xuwei2023@gzhmu.edu.cn., Hu Y; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China., Zhang Y; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China., Schnepp PM; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA., Lo LM; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA., Zhang Q; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA., Cheng SM; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA., Chen X; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China. chenx9@sustech.edu.cn.
Source: Nature protocols [Nat Protoc] 2026 Jul; Vol. 21 (7), pp. 3227-3259. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE
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  Data: Single-nucleus chromatin accessibility and gene expression co-profiling by ISSAAC-seq.
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  Data: <searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangdong, China. xuwei2023@gzhmu.edu.cn.; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China. xuwei2023@gzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Schnepp+PM%22">Schnepp PM</searchLink>; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lo+LM%22">Lo LM</searchLink>; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+SM%22">Cheng SM</searchLink>; Bio-Rad Laboratories, Life Science Group, Pleasanton, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China. chenx9@sustech.edu.cn.
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        Value: 10.1038/s41596-025-01304-y
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              Text: 2026 Jul
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