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Interpretable inflammation landscape of circulating immune cells.

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Title: Interpretable inflammation landscape of circulating immune cells.
Authors: Jiménez-Gracia L; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.; Omniscope, Barcelona, Spain., Maspero D; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain., Aguilar-Fernández S; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Craighero F; Signal Processing Laboratory 2 (LTS2), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Boulougouri M; Signal Processing Laboratory 2 (LTS2), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Ruiz M; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain., Marchese D; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain., Caratù G; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain., Liñares-Blanco J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.; Department of Statistics, University of Granada, Granada, Spain., Berasategi M; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain., Ramirez Flores RO; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Sanzo-Machuca A; Inflammatory Bowel Disease Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Corraliza AM; Inflammatory Bowel Disease Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Tran HA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Normand R; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Nestor J; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Hong Y; Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium., Kole T; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., van der Velde P; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Alleblas F; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Pedretti F; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Aterido A; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.; IMIDomics, Inc., San Rafael, CA, USA., Banchero M; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Soriano G; Department of Gastroenterology, Biomedical Research Institut Sant Pau (IIB Sant Pau), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain., Román E; Department of Gastroenterology, Biomedical Research Institut Sant Pau (IIB Sant Pau), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain., van den Berge M; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Salas A; Inflammatory Bowel Disease Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Carrascosa JM; Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., Fernández Nebro A; UGC de Reumatología, Hospital Regional Universitario de Málaga, Malaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga, Spain.; Departamento de Medicina, Universidad de Málaga, Malaga, Spain., Domènech E; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., Cañete JD; Rheumatology Department, Fundació Clínic per a la Recerca Biomèdica, Barcelona, Spain., Tornero J; Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain., Gisbert JP; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain.; Universidad Autónoma de Madrid (UAM), Madrid, Spain., Choy E; Section of Rheumatology, Cardiff University, Cardiff, UK., Girolomoni G; Section of Dermatology and Venereology, University of Verona, Verona, Italy., Siegmund B; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Cluster of Excellence ImmunoPreCept, Charité - Universitätsmedizin Berlin, Berlin, Germany., Julià A; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.; IMIDomics, Inc., San Rafael, CA, USA., Serra V; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Elosua R; Hospital del Mar Research Institute (IMIM), Barcelona, Spain.; CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.; Faculty of Medicine, University of Vic-Central University of Catalonia, Vic, Spain., Tejpar S; Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium., Vidal S; Group of Immunology-Inflammatory Diseases, Biomedical Research Institut Sant Pau (IIB Sant Pau), Barcelona, Spain., Nawijn MC; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Gut I; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Marsal S; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.; IMIDomics, Inc., San Rafael, CA, USA., Villani AC; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA., Nieto JC; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain. juan.nieto@cnag.eu.; Universitat de Barcelona, Barcelona, Spain. juan.nieto@cnag.eu., Heyn H; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain. holger.heyn@cnag.eu.; Universitat de Barcelona, Barcelona, Spain. holger.heyn@cnag.eu.; ICREA, Barcelona, Spain. holger.heyn@cnag.eu.
Source: Nature medicine [Nat Med] 2026 Feb; Vol. 32 (2), pp. 633-644. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jiménez-Gracia+L%22">Jiménez-Gracia L</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain.; Omniscope, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Maspero+D%22">Maspero D</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Aguilar-Fernández+S%22">Aguilar-Fernández S</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Craighero+F%22">Craighero F</searchLink>; Signal Processing Laboratory 2 (LTS2), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boulougouri+M%22">Boulougouri M</searchLink>; Signal Processing Laboratory 2 (LTS2), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ruiz+M%22">Ruiz M</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Marchese+D%22">Marchese D</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Caratù+G%22">Caratù G</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Liñares-Blanco+J%22">Liñares-Blanco J</searchLink>; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.; Department of Statistics, University of Granada, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Berasategi+M%22">Berasategi M</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ramirez+Flores+RO%22">Ramirez Flores RO</searchLink>; 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Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Soriano+G%22">Soriano G</searchLink>; Department of Gastroenterology, Biomedical Research Institut Sant Pau (IIB Sant Pau), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Román+E%22">Román E</searchLink>; Department of Gastroenterology, Biomedical Research Institut Sant Pau (IIB Sant Pau), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22van+den+Berge+M%22">van den Berge M</searchLink>; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, Groningen, Netherlands.; Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Salas+A%22">Salas A</searchLink>; Inflammatory Bowel Disease Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carrascosa+JM%22">Carrascosa JM</searchLink>; Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+Nebro+A%22">Fernández Nebro A</searchLink>; UGC de Reumatología, Hospital Regional Universitario de Málaga, Malaga, Spain.; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga, Spain.; Departamento de Medicina, Universidad de Málaga, Malaga, Spain.<br /><searchLink fieldCode="AU" term="%22Domènech+E%22">Domènech E</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; Gastroenterology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Cañete+JD%22">Cañete JD</searchLink>; Rheumatology Department, Fundació Clínic per a la Recerca Biomèdica, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tornero+J%22">Tornero J</searchLink>; Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain.<br /><searchLink fieldCode="AU" term="%22Gisbert+JP%22">Gisbert JP</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain.; Universidad Autónoma de Madrid (UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Choy+E%22">Choy E</searchLink>; Section of Rheumatology, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Girolomoni+G%22">Girolomoni G</searchLink>; Section of Dermatology and Venereology, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Siegmund+B%22">Siegmund B</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Cluster of Excellence ImmunoPreCept, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Julià+A%22">Julià A</searchLink>; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.; IMIDomics, Inc., San Rafael, CA, USA.<br /><searchLink fieldCode="AU" term="%22Serra+V%22">Serra V</searchLink>; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Elosua+R%22">Elosua R</searchLink>; Hospital del Mar Research Institute (IMIM), Barcelona, Spain.; CIBERCV, Instituto de Salud Carlos III, Madrid, Spain.; 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Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Marsal+S%22">Marsal S</searchLink>; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.; IMIDomics, Inc., San Rafael, CA, USA.<br /><searchLink fieldCode="AU" term="%22Villani+AC%22">Villani AC</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA.; Broad Institute of MIT and Harvard, Charlestown, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nieto+JC%22">Nieto JC</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain. juan.nieto@cnag.eu.; Universitat de Barcelona, Barcelona, Spain. juan.nieto@cnag.eu.<br /><searchLink fieldCode="AU" term="%22Heyn+H%22">Heyn H</searchLink>; Centro Nacional de Análisis Genómico, C/Baldiri Reixac 4, Barcelona, Spain. holger.heyn@cnag.eu.; Universitat de Barcelona, Barcelona, Spain. holger.heyn@cnag.eu.; ICREA, Barcelona, Spain. holger.heyn@cnag.eu.
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            NameFull: Fernández Nebro A
      – PersonEntity:
          Name:
            NameFull: Domènech E
      – PersonEntity:
          Name:
            NameFull: Cañete JD
      – PersonEntity:
          Name:
            NameFull: Tornero J
      – PersonEntity:
          Name:
            NameFull: Gisbert JP
      – PersonEntity:
          Name:
            NameFull: Choy E
      – PersonEntity:
          Name:
            NameFull: Girolomoni G
      – PersonEntity:
          Name:
            NameFull: Siegmund B
      – PersonEntity:
          Name:
            NameFull: Julià A
      – PersonEntity:
          Name:
            NameFull: Serra V
      – PersonEntity:
          Name:
            NameFull: Elosua R
      – PersonEntity:
          Name:
            NameFull: Tejpar S
      – PersonEntity:
          Name:
            NameFull: Vidal S
      – PersonEntity:
          Name:
            NameFull: Nawijn MC
      – PersonEntity:
          Name:
            NameFull: Gut I
      – PersonEntity:
          Name:
            NameFull: Saez-Rodriguez J
      – PersonEntity:
          Name:
            NameFull: Marsal S
      – PersonEntity:
          Name:
            NameFull: Villani AC
      – PersonEntity:
          Name:
            NameFull: Nieto JC
      – PersonEntity:
          Name:
            NameFull: Heyn H
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1546-170X
          Numbering:
            – Type: volume
              Value: 32
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Nature medicine
              Type: main
ResultId 1