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Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX).

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Title: Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX).
Authors: Burchert A; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany. burchert@staff.uni-marburg.de., Nicolini FE; Centre Hospitalier Lyon Sud, Lyon, Cedex 03, France., le Coutre P; Department of Hematology, Oncology and Tumor Immunology, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Saussele S; Clinic for Hematology and Oncology, University Heidelberg, Mannheim, Germany., Hochhaus A; Hematology/Oncology, Jena University Hospital, Jena, Germany., Tuere E; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Metzelder SK; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Pauck K; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, University Marburg, Marburg, Germany., Garn H; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, University Marburg, Marburg, Germany., Raifer H; Institute of Systems Immunology, University Marburg, Marburg, Germany., Huber M; Institute of Systems Immunology, University Marburg, Marburg, Germany., Gattermann N; Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany., Crysandt M; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen, Germany., Schafhausen P; Department of Internal medicine II, University Medical Centre of Hamburg-Eppendorf, Hamburg, Germany., Bormann M; Klinikum Bremen Mitte, Bremen, Germany., Radsak MP; Department of Internal Medicine III, University Medical Center, Johannes Gutenberg-University of Mainz, Mainz, Germany., Guerci-Bresler A; Service d'Hématologie, Centre Hospitalier Universitaire Brabois, Vandoeuvre- lès-, Nancy, France., Illmer T; Group Practice for Hematology and Oncology, Dresden, Germany., Goebeler ME; CCC Trial Office, Würzburg, Germany., Herhaus P; Internal Medicine III, School of Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Teichmann LL; Center for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf (CIO ABCD), Bonn, Germany., Franke GN; Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany., Lang F; Dept. of Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany., Krause SW; Uniklinikum Erlangen, Medicine 5, Erlangen, Germany., Möhle R; Department of Hematology and Oncology, University of Tübingen, Tübingen, Germany., Klausmann M; Practice for Hematology, Oncology and Gastroeneterology, Aschaffenburg, Germany., Stegelmann F; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Lutz C; Praxis for Hematology and Oncology, Koblenz, Germany., Etienne G; Groupe Fi-LMC, Institut Bergonié, Bordeaux, France., Stoltefuß A; Evangelisches Krankenhaus Hamm, Hamm, Germany., Göthert JR; Department of Hematology and Stem Cell Transplantation, West German Cancer center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Ernst T; Hematology/Oncology, Jena University Hospital, Jena, Germany., Abu-Samra M; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Giessen, Germany., Höffkes HG; Tumorklinik (Medizinische Onkologie, Palliativmedizin, Hämatologie und Hämostaseologie), Klinikum Fulda, Fulda, Germany., Neubauer A; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Wang Y; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Weiland P; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Otto C; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Kiessler L; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Weber T; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Kroning L; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany., Nist A; Genomics Core Facility, Institute of Molecular Oncology, Member of the German Center for Lung Research (DZL), Philipps University Marburg, Marburg, Germany; Institute of Lung Health (ILH), Justus Liebig University, Giessen, 35392, Germany., Stiewe T; Genomics Core Facility, Institute of Molecular Oncology, Member of the German Center for Lung Research (DZL), Philipps University Marburg, Marburg, Germany; Institute of Lung Health (ILH), Justus Liebig University, Giessen, 35392, Germany., Hehlmann R; Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany, and ELN-Foundation, Weinheim, Germany., Aminossadati B; Marburg University, Faculty of Medicine, Coordinating Center for Clinical Trials, Marburg, Germany., Wittenberg M; Marburg University, Faculty of Medicine, Coordinating Center for Clinical Trials, Marburg, Germany., Winterstein K; Marburg University, Faculty of Medicine, Coordinating Center for Clinical Trials, Marburg, Germany., Oellerich T; Dept. of Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany., Lechner M; Center for Synthetic Microbiology, SYNMIKRO, University Marburg, Marburg, Germany., Pfirrmann M; Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Medizinische Fakultät, Ludwig-Maximilians-Universität, Munich, Germany., Schade-Brittinger C; Marburg University, Faculty of Medicine, Coordinating Center for Clinical Trials, Marburg, Germany., Klemm P; Center for Synthetic Microbiology, SYNMIKRO, University Marburg, Marburg, Germany., Michel C; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany.
Source: Leukemia [Leukemia] 2026 Feb; Vol. 40 (2), pp. 410-417. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Randomized phase 3 trial of Ropeginterferon alfa-2b versus surveillance after tyrosine kinase inhibitor discontinuation in chronic myeloid leukemia (ENDURE/CML-IX).
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  Data: <searchLink fieldCode="AU" term="%22Burchert+A%22">Burchert A</searchLink>; Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg University, Marburg, Germany. burchert@staff.uni-marburg.de.<br /><searchLink fieldCode="AU" term="%22Nicolini+FE%22">Nicolini FE</searchLink>; Centre Hospitalier Lyon Sud, Lyon, Cedex 03, France.<br /><searchLink fieldCode="AU" term="%22le+Coutre+P%22">le Coutre P</searchLink>; Department of Hematology, Oncology and Tumor Immunology, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Saussele+S%22">Saussele S</searchLink>; Clinic for Hematology and Oncology, University Heidelberg, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Hochhaus+A%22">Hochhaus A</searchLink>; Hematology/Oncology, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Tuere+E%22">Tuere E</searchLink>; 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            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-5551
          Numbering:
            – Type: volume
              Value: 40
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Leukemia
              Type: main
ResultId 1