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Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling.

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Title: Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling.
Authors: Moral-Sanz J; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain. javier.moralsanz@syneoshealth.com.; Syneos Health, Madrid, Spain. javier.moralsanz@syneoshealth.com., Fernández-Carrasco I; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain., Ramponi V; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Garrido A; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA., Karbat I; Departments of Biomolecular Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Cabezas-Sainz P; Department of Zoology, Genetics and Physical Anthropology, Universidad de Santiago de Compostela, Lugo, Spain., Rivera-de-Torre E; Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University, Madrid, Spain.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Elsallabi O; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Department of Medicine and Science of Aging, University 'G. d'Annunzio' of Chieti Pescara, Chieti, Italy., Martín-Hernández R; Cheminformatics & Artificial Intelligence Group, Madrid Institute for Advances Studies in Nutrition (IMDEA Nutrition), Madrid, Spain., López-Aceituno JL; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain., Price NL; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA., Sanchez L; Department of Zoology, Genetics and Physical Anthropology, Universidad de Santiago de Compostela, Lugo, Spain., Colmenarejo G; Cheminformatics & Artificial Intelligence Group, Madrid Institute for Advances Studies in Nutrition (IMDEA Nutrition), Madrid, Spain., Martínez-Del-Pozo Á; Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University, Madrid, Spain., Vetter I; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.; School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Woolloongabba, Queensland, Australia., Cogolludo A; Department of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain., Perez-Vizcaino F; Department of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain., Del-Pozo J; R(D)SVS, University of Edinburgh, Easter Bush Campus, Roslin, Edinburgh, UK., Reuveny E; Departments of Biomolecular Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Fernández-Rojo MA; Hepatic Regenerative Medicine Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.; Frazer Institute, Translational Research Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Robbins PD; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., de Cabo R; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.; Nutritional Interventions Group. Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain., Serrano M; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Altos Labs, Cambridge Institute of Science, Granta Park, UK., Ikonomopoulou MP; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain. maria.ikonomopoulou@nutricion.imdea.org.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia. maria.ikonomopoulou@nutricion.imdea.org.
Source: Nature aging [Nat Aging] 2026 Feb; Vol. 6 (2), pp. 349-367. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling.
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  Data: <searchLink fieldCode="AU" term="%22Moral-Sanz+J%22">Moral-Sanz J</searchLink>; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain. javier.moralsanz@syneoshealth.com.; Syneos Health, Madrid, Spain. javier.moralsanz@syneoshealth.com.<br /><searchLink fieldCode="AU" term="%22Fernández-Carrasco+I%22">Fernández-Carrasco I</searchLink>; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ramponi+V%22">Ramponi V</searchLink>; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Garrido+A%22">Garrido A</searchLink>; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Karbat+I%22">Karbat I</searchLink>; Departments of Biomolecular Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Cabezas-Sainz+P%22">Cabezas-Sainz P</searchLink>; Department of Zoology, Genetics and Physical Anthropology, Universidad de Santiago de Compostela, Lugo, Spain.<br /><searchLink fieldCode="AU" term="%22Rivera-de-Torre+E%22">Rivera-de-Torre E</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University, Madrid, Spain.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Elsallabi+O%22">Elsallabi O</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Department of Medicine and Science of Aging, University 'G. d'Annunzio' of Chieti Pescara, Chieti, Italy.<br /><searchLink fieldCode="AU" term="%22Martín-Hernández+R%22">Martín-Hernández R</searchLink>; Cheminformatics & Artificial Intelligence Group, Madrid Institute for Advances Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Aceituno+JL%22">López-Aceituno JL</searchLink>; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Price+NL%22">Price NL</searchLink>; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez+L%22">Sanchez L</searchLink>; Department of Zoology, Genetics and Physical Anthropology, Universidad de Santiago de Compostela, Lugo, Spain.<br /><searchLink fieldCode="AU" term="%22Colmenarejo+G%22">Colmenarejo G</searchLink>; Cheminformatics & Artificial Intelligence Group, Madrid Institute for Advances Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Del-Pozo+Á%22">Martínez-Del-Pozo Á</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vetter+I%22">Vetter I</searchLink>; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.; School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Woolloongabba, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Cogolludo+A%22">Cogolludo A</searchLink>; Department of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Perez-Vizcaino+F%22">Perez-Vizcaino F</searchLink>; Department of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Del-Pozo+J%22">Del-Pozo J</searchLink>; R(D)SVS, University of Edinburgh, Easter Bush Campus, Roslin, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Reuveny+E%22">Reuveny E</searchLink>; Departments of Biomolecular Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Fernández-Rojo+MA%22">Fernández-Rojo MA</searchLink>; Hepatic Regenerative Medicine Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.; Frazer Institute, Translational Research Institute, The University of Queensland, Woolloongabba, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22de+Cabo+R%22">de Cabo R</searchLink>; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.; 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Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Serrano+M%22">Serrano M</searchLink>; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Altos Labs, Cambridge Institute of Science, Granta Park, UK.<br /><searchLink fieldCode="AU" term="%22Ikonomopoulou+MP%22">Ikonomopoulou MP</searchLink>; Translational Venomics Group, Madrid Institute for Advanced Studies in Nutrition (IMDEA Nutrition), Madrid, Spain. maria.ikonomopoulou@nutricion.imdea.org.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia. maria.ikonomopoulou@nutricion.imdea.org.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Feb; Vol. 6 (2), pp. 349-367. <i>Date of Electronic Publication: </i>2026 Jan 12.
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