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Monitoring biological effects of somatic cell genome editing.

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Title: Monitoring biological effects of somatic cell genome editing.
Authors: Freedman BS; Department of Medicine, Division of Nephrology, Kidney Research Institute, and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. benof@uw.edu.; Plurexa LLC, Seattle, WA, USA. benof@uw.edu., Bulte JWM; Department of Radiology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Conklin BR; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Judge LM; Gladstone Institutes, San Francisco, CA, USA.; Department of Pediatrics, University of California, San Francisco, CA, USA., Dwinell MR; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Geurts AM; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Sitton MJ; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Mahajan V; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Basic and Translational Research, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA., Kiani S; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Gersbach CA; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Ebrahimkhani MR; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Kelly JJ; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Ronald JA; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada., Morizane R; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gupta N; Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA., Shakeri-Zadeh A; Department of Radiology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Vo N; Department of Medicine, Division of Nephrology, Kidney Research Institute, and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Saha K; Departments of Biomedical Engineering and Pediatrics, and McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA., Saxena S; Departments of Biomedical Engineering and Pediatrics, and McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA., Gamm DM; Department of Ophthalmology and Visual Sciences, Waisman Center, and McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA., Sinha D; Department of Ophthalmology and Visual Sciences, Waisman Center, and McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA., Tarantal AF; Departments of Pediatrics and Cell Biology and Human Anatomy, School of Medicine, and California National Primate Research Center, University of California Davis, Davis, CA, USA., Vandsburger M; Department of Bioengineering, University of California Berkley, Berkeley, CA, USA., Matsubara A; Department of Hematology, St Jude's Children's Research Hospital, Memphis, TN, USA., Fu H; Department of Medicine, Division of Nephrology, Kidney Research Institute, and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Tsai SQ; Department of Hematology, St Jude's Children's Research Hospital, Memphis, TN, USA.
Corporate Authors: SCGE Dissemination and Coordinating Center Toolkit Team, SCGE Biological Effects Initiative
Source: Nature reviews. Genetics [Nat Rev Genet] 2026 Apr; Vol. 27 (4), pp. 323-342. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962779 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0064 (Electronic) Linking ISSN: 14710056 NLM ISO Abbreviation: Nat Rev Genet Subsets: MEDLINE
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