Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs.

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Title: Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs.
Authors: Lee JM; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Raeder PL; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Rashid RB; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Zhang H; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Nelson CS; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA., Richardson SG; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Burke KP; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Chandrakar P; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Podestà MA; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Unit of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Gempler MG; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA., Batty C; Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, MA, USA., Kong D; Department of Surgery and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA., Gavzy SJ; Department of Surgery and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA., Shirkey MW; Department of Surgery and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA., Yang C; TaiwanBio Therapeutics, Taipei, Taiwan., Bromberg JS; Department of Surgery and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA., Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Marasco WA; Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, MA, USA., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Sage PT; Department of Medicine, Transplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA. psage@bwh.harvard.edu.
Source: Nature immunology [Nat Immunol] 2026 Feb; Vol. 27 (2), pp. 336-347. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-025-02373-7