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GCN5-ERK lactylation-phosphorylation loop amplifies lactate-driven cancer progression.

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Title: GCN5-ERK lactylation-phosphorylation loop amplifies lactate-driven cancer progression.
Authors: Huang B; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China., Jin M; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China., Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Wang Z; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China., Wang F; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Chen M; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China., Zhu L; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China., Li Y; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang X; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China.; Institute of Materia Medical, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Li R; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China., Wu J; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China., Zhai L; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China., He Y; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China.; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China., Yang J; Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China., Ding X; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China., Wang Q; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China., Xv Z; Department of Clinical Laboratory, The Affiliated East Hospital of Tongji University, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Shanghai Immune Therapy Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China., Ouyang Y; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Li J; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China., Yang Y; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China., Li K; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Lou Z; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA., Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Zhang J; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. zhangjingwt@tongji.edu.cn.; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. zhangjingwt@tongji.edu.cn.; Institute for Advanced Study, Tongji University, Tongji University, Shanghai, China. zhangjingwt@tongji.edu.cn., Chen Y; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China. 1610600@tongji.edu.cn.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China. 1610600@tongji.edu.cn., Yuan J; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. yuanjian229@hotmail.com.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China. yuanjian229@hotmail.com.; Clinical Center for Brain and Spinal Cord Research, Tongji University, Shanghai, China. yuanjian229@hotmail.com.; Affliated Shanghai Blue Cross Brain Hospital, School of Medicine, Tongji University, Shanghai, China. yuanjian229@hotmail.com., Zhong C; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. drchunlongzhong@tongji.edu.cn.
Source: Nature chemical biology [Nat Chem Biol] 2026 Apr; Vol. 22 (4), pp. 634-648. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: GCN5-ERK lactylation-phosphorylation loop amplifies lactate-driven cancer progression.
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  Data: <searchLink fieldCode="AU" term="%22Huang+B%22">Huang B</searchLink>; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Jin+M%22">Jin M</searchLink>; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cui+G%22">Cui G</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; 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Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Ding+X%22">Ding X</searchLink>; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xv+Z%22">Xv Z</searchLink>; Department of Clinical Laboratory, The Affiliated East Hospital of Tongji University, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.; 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Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lou+Z%22">Lou Z</searchLink>; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mer+G%22">Mer G</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. zhangjingwt@tongji.edu.cn.; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. zhangjingwt@tongji.edu.cn.; Institute for Advanced Study, Tongji University, Tongji University, Shanghai, China. zhangjingwt@tongji.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China. 1610600@tongji.edu.cn.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China. 1610600@tongji.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; State Key Laboratory of Cardiology and Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. yuanjian229@hotmail.com.; Cancer Research Center, Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai, China. yuanjian229@hotmail.com.; Clinical Center for Brain and Spinal Cord Research, Tongji University, Shanghai, China. yuanjian229@hotmail.com.; Affliated Shanghai Blue Cross Brain Hospital, School of Medicine, Tongji University, Shanghai, China. yuanjian229@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Zhong+C%22">Zhong C</searchLink>; Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. drchunlongzhong@tongji.edu.cn.
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